Reply to M. Dhanushkodi

Bassey, Iya Eze; Essien, Okon; Gali, Rebecca Mtaku; Udoh, A. E.; Akpan, Uwem Okon; Glen, Enakirerhi E.

doi:10.1200/jgo.2016.006130

Cited by 2 publications

(2 citation statements)

References 2 publications

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“…Among females, the highest percentage of morbidity cause was malignant neoplasm of breast (ICD.10:C50; n=441, 10.9%) followed by secondary malignant neoplasm of other and unspecified sites (ICD.10:C79; n=215, 5.3%) and malignant neoplasm of cervix uteri (ICD.10:C53; n= 117, 2.9%). Study by Udoh et al [21] reported that 44.1% of the geriatric morbidity was due to communicable diseases while 55.9% were due to noncommunicable diseases. The present study showed that high point in the frequency of morbidities was found in the hot-wet (n= 5273, 26.9%) season (July: 8.4%, August: 8.9% and September: 9.6% month) followed by winter (n= 4496, 22.9%) season (December: 8.3%, January: 7.5% and February: 7.1%).…”

Section: Resultsmentioning

confidence: 99%

A Study on Morbidity Patterns amongst Hospitalized Patients Attending a New Tertiary Care Institute, India

Tyagi¹,

Mohanti²,

Ganesh³

et al. 2016

APJHS

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Background:The pattern of morbidity reflects the burden of disease in a particular community. This pattern shows geographic variations between communities and countries. The knowledge of the pattern of diseases in a given country is very important in evaluating its health care delivery system. Such knowledge is important for health planning and for improving the healthcare services in that particular nation. We set out to study the morbidity pattern in our medical wards. Materials and methods: This is a retrospective study that reviewed the causes of morbidity amongst admitted cases from January 2014 to December 2014. The data were obtained from the medical record section. Data were analyzed using software Statistical Package for Social Sciences (SPSS) version 16. Results: A total of 19,609 patients were admitted during the study period. Of these males were 10,556 (53.8%) and females were 9,053 (46.2%). Out of the total cases, 19203 patients (97.9%) were discharged or relieved as cured, 210 patients (1.1%) had expired. The sex ratio was 858 females to 1,000 males. Of the most common causes of morbidities/system involved (ICD.10) in males, chronic ischemic heart disease (4.7%) was the leading cause followed by live born infants (3.8%), hypertension (3.7%), lymphoid leukemia (2.7%) and malignant neoplasm of brain (2.1%). In females, malignant neoplasm of breast (6.2%) was the leading cause followed by delivery by caesarean section (4.9%), live born infants (3.8%), secondary malignant neoplasm of other and unspecified sites (3.1%) and hypertension (2.4%). Overall bed occupancy rate (BOR) for all patients was 66.8 percent. Conclusion: Morbidity in the medical wards reflects the emerging trend of mixed disease spectrum burden comprising communicable and non-communicable diseases. Public health education, raising the socio-economic status of our people and as well as improving the standards of our health care facilities and personnel can contribute towards bringing down morbidity and mortality rates from medical wards.

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Section: Resultsmentioning

confidence: 99%

A Study on Morbidity Patterns amongst Hospitalized Patients Attending a New Tertiary Care Institute, India

Tyagi¹,

Mohanti²,

Ganesh³

et al. 2016

APJHS

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“…ardiovascular diseases (CVDs) remain the most common non-communicable disease and the leading cause of mortality and disability worldwide, as per the world health organization, expected to cause more or less 23 million deaths by 2030 [1][2][3][4]. In addition to the high level of mortality rates, CVDs cause decrement in quality of life at the micro-level in patients and their families, as well as a result in a crucial financial burden on the health budget of countries, particularly those with low-and middle-incomes, at the macro-level [5][6][7].…”

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confidence: 99%

The Functionality of Apigenin as a Novel Cardioprotective Nutraceutical with Emphasize on Regulating Cardiac Micro RNAs

Raberi

Esmati

Bodagh

et al. 2022

GMJ

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Cardiovascular diseases (CVDs) are considered the most common disorder and the leading cause of mortality globally. The etiology of CVDs depends on a variety of genetic and acquired parameters. Nowadays, a dramatic surge appeared in published reports to find the association between microRNAs (miRNAs) and CVDs in order to understand the cause of the disease, rapid diagnosis with the introduction of valid biomarkers, and target as a therapeutic approach. Apigenin is a novel nutraceutical flavonoid that cardioprotective properties are suggested. The current review aimed to evaluate the beneficial features of this phytochemical against CVDs with an emphasis on its ability to regulate the miRNAs. The findings demonstrated that Apigenin could regulate cardiac miRNAs, including miR-103, miR-122-5p, miR-15b, miR-155, and miR-33. Consequently, preventing CVDs is possible through different effects such as the promotion of cholesterol efflux, prevention of hyperlipidemia, alteration in ATP Binding Cassette Subfamily A Member 1 (ABCA1) levels, reducing of cardiocytes apoptosis, and retarding myocytes fibrosis. Also, it can regulate signaling pathways, protect against endothelial dysfunction, maintain oxidative balance, and decrease inflammatory factors and reactive oxygen species. Hence, apigenin regulatory characteristics affecting miRNAs expression could introduce this flavonoid as a novel cardioprotective phytochemical against different CVDs.

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Reply to M. Dhanushkodi

Cited by 2 publications

References 2 publications

A Study on Morbidity Patterns amongst Hospitalized Patients Attending a New Tertiary Care Institute, India

A Study on Morbidity Patterns amongst Hospitalized Patients Attending a New Tertiary Care Institute, India

The Functionality of Apigenin as a Novel Cardioprotective Nutraceutical with Emphasize on Regulating Cardiac Micro RNAs

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