Reply to Nifli, A.-P. Comment on “Rosell-Cardona et al. Dietary Spray-Dried Porcine Plasma Reduces Neuropathological Alzheimer’s Disease Hallmarks in SAMP8 Mice. Nutrients 2021, 13, 2369”

Abstract

Thank you for your comments on our recent work of the effects of supplementation with spray-dried porcine plasma (SDP) on neuropathological markers of Alzheimer’s disease (AD) [...]

The Neuroprotective Effects of Spray-Dried Porcine Plasma Supplementation Involve the Microbiota−Gut−Brain Axis

“…Mechanisms of communication between the gut microbiota and brain primarily involve the regulation of the immune system and the activation of neural and endocrine pathways by the gut microbiota or its by-products [ 31 ]. Dietary supplementation with SDP improves brain resilience against the neuropathological hallmarks of AD [ 15 ] and prevents the cognitive decline in SAMP8 mice [ 19 ]. Previous studies have shown that SDP supplementation has anti-inflammatory properties because it can modulate the mucosal immune response.…”

“…Spray-dried porcine plasma (SDP) is a functional protein source that contents many functional components such as albumin, immunoglobulins, transferrin, fibrinogen, growth factors and many other peptides that not only promote intestinal function but also have systemic effects beyond the intestine, such as on the respiratory and reproductive systems [ 15 , 16 , 17 , 18 ]. Using aged senescence-accelerated prone (SAMP8) mice, we have previously shown that dietary supplementation with SDP prevents cognitive decline and reduces neuroinflammation and oxidative stress in the central nervous system [ 19 ] and decreases the neuropathological hallmarks of AD [ 20 ].…”