Reply to “the critical role of pre-publication peer review—a case study of glyphosate” by FN Dost

Guyton, Kathryn Z.; Loomis, Dana; Straif, Kurt

doi:10.1007/s11356-016-7675-0

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…These included mainly diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos. [50][51][52][53][54][55][56] It has been stated that it would be crucial to focus on parental exposure to pesticides, herbicides, insecticides, and other household chemicals and pediatric cancer while emphasizing evidence-based, proactive measures. They may include the wearing of chemical-resistant gloves during pesticide application and, even the application of chemicals for household cleaning.…”

Section: Discussionmentioning

confidence: 99%

Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary

2022

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Background There are hereditary types of nephroblastoma or Wilms’ tumor associated with exposure of the germ cells of either parent to harmful environmental factors. Some studies have examined the exposure of compounds used pesticides and herbicides as a risk factor for Wilms’ tumor. Methods A systematic review and meta-analysis were carried out on case-control studies to establish the potential link between exposure to these organic molecules and Wilms’ tumor occurrence in children rigorously. We examined the monographs on some organo-phosphate insecticides and herbicides issued by the International Association for the Research on Cancer (IARC) under the auspices of the World Health Organization (WHO). PUBMED, SCOPUS, and Google Scholar studies (1960–2021) were identified and systematically reviewed following Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines. Subgroup analyses were conducted after stratification for occupational versus residential exposure and before birth (prenatal) vs. after birth (postnatal) exposure. In addition, we revised the monographs on chemical compounds issued recently by the IARC/WHO. Results Our findings seem to consolidate that parental pesticide exposure during the preconception or pregnancy period is correlated with an increased occurrence risk for Wilms’ tumor. We confirm the validity of the WHO essays on certain organophosphate herbicides and insecticides, which support these compounds, may be highly relevant in future cancer prevention policies. Conclusion Parental exposure to pesticides, particularly in household settings, is poorly emphasized in our society. There is a strong association between these organophosphate compounds and pediatric cancer. Public health agencies may need to take stronger action than in the past.

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Section: Discussionmentioning

confidence: 99%

Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary

2022

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“…Considering our findings, global and concerted actions to raise awareness of CBT risk and pesticide exposure are worthwhile. For instance, experts from countries already met at the international level to assess the carcinogenicity of the organophosphate pesticides, which include tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate [ 25 , 67 , 68 , 69 , 70 , 71 , 72 ]. In the future, it will be more helpful to focus on parental exposure and pediatric cancer while emphasizing evidence-based, proactive measures such as the wearing of chemical-resistant gloves during pesticide application.…”

Section: Discussionmentioning

confidence: 99%

Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides

et al. 2021

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Background: Brain tumors are the second most common neoplasm in the pediatric age. Pesticides may play an etiologic role, but literature results are conflicting. This review provides a systematic overview, meta-analysis, and IARC/WHO consideration of data on parental exposure to pesticides and childhood brain tumors. Methods: We searched PubMed, SCOPUS, and Google Scholar for literature (1 January 1966–31 December 2020) that assessed childhood brain tumors and parental exposure to pesticides. We undertook a meta-analysis addressing prenatal exposure, exposure after birth, occupational exposure, and residential exposure. A total of 130 case-control investigations involving 43,598 individuals (18,198 cases and 25,400 controls) were included. Results: Prenatal exposure is associated with childhood brain tumors (odds ratio, OR = 1.32; 95% CI: 1.17–1.49; I2 = 41.1%). The same occurs after birth exposure (OR = 1.22; 95% CI: 1.03–1.45, I2 = 72.3%) and residential exposure to pesticides (OR = 1.31; 95% CI: 1.11–1.54, I2 = 67.2%). Parental occupational exposure is only marginally associated with CBT (OR = 1.17, 95% CI: 0.99–1.38, I2 = 67.0%). Conclusions: There is an association between CBT and parental pesticides exposure before childbirth, after birth, and residential exposure. It is in line with the IARC Monograph evaluating the carcinogenicity of diazinon, glyphosate, malathion, parathion, and tetrachlorvinphos.

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Pre-conceptional and prenatal exposure to pesticides and pediatric neuroblastoma. A meta-analysis of nine studies

Khan

Feulefack

Sergi

2022

Environmental Toxicology and Pharmacology

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Reply to “the critical role of pre-publication peer review—a case study of glyphosate” by FN Dost

Cited by 3 publications

References 5 publications

Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary

Exposure to pesticides and pediatric Wilms’ tumor. A meta-analysis on pre-conception and pregnancy parental exposure with an IARC/WHO commentary

Parental Pesticide Exposure and Childhood Brain Cancer: A Systematic Review and Meta-Analysis Confirming the IARC/WHO Monographs on Some Organophosphate Insecticides and Herbicides

Pre-conceptional and prenatal exposure to pesticides and pediatric neuroblastoma. A meta-analysis of nine studies

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