Reply to: The diagnostic accuracy of 18F-FDG PET in cutaneous malignant melanoma

Delgado-Bolton, Roberto; Jiménez-Requena, Felisa; Fernández-Pérez, Cristina; Gambhir, Sanjiv S.; Schwimmer, Judy; Pérez-Vázquez, J.M.; Carreras-Delgado, J.L.

doi:10.1007/s00259-010-1476-3

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(2 citation statements)

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“…Most cases with clinically localized melanoma show no evidence of disseminated disease and if they do, metastases are often of minimal size. In this type of patients, the yield of FDG-PET/CT is hindered by its limited spatial resolution in contrast with the previously mentioned SNB, which benefits from microscopic examination [ 110 , 111 ]. The lack of usefulness of FDG-PET/CT has already been described for metastasis detection in cases of clinically localized melanoma [ 109 ] and the superiority of SNB has been advocated in a systematic review [ 114 ].…”

Section: Lymphoscintigraphy Improves the Accuracy Of Sentinel Lymph Nmentioning

confidence: 99%

“…The lack of usefulness of FDG-PET/CT has already been described for metastasis detection in cases of clinically localized melanoma [ 109 ] and the superiority of SNB has been advocated in a systematic review [ 114 ]. Moreover, in a study including 64 T2–T4 melanoma patients, preoperative FDG-PET/CT was positive in only two out of 19 patients with subsequently confirmed metastases in surgically removed SNs [ 110 ]. However, in individual clinical situations assuming a high risk of metastasis (Breslow > 4 mm, presence of ulceration and high mitotic index and trunk and upper extremities), some authors consider that this technique could provide useful information [ 111 ].…”

Section: Lymphoscintigraphy Improves the Accuracy Of Sentinel Lymph Nmentioning

confidence: 99%

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Melanoma & Nuclear Medicine: New Insights & Advances

et al. 2018

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The contribution of nuclear medicine to management of melanoma patients is increasing. In intermediate-thickness N0 melanomas, lymphoscintigraphy provides a roadmap for sentinel node biopsy. With the introduction of single-photon emission computed tomography images with integrated computed tomography (SPECT/CT), 3D anatomic environments for accurate surgical planning are now possible. Sentinel node identification in intricate anatomical areas (pelvic cavity, head/neck) has been improved using hybrid radioactive/fluorescent tracers, preoperative lymphoscintigraphy and SPECT/CT together with modern intraoperative portable imaging technologies for surgical navigation (free-hand SPECT, portable gamma cameras). Furthermore, PET/CT today provides 3D roadmaps to resect 18F-fluorodeoxyglucose-avid melanoma lesions. Simultaneously, in advanced-stage melanoma and recurrences, 18F-fluorodeoxyglucose-PET/CT is useful in clinical staging and treatment decision as well as in the evaluation of therapy response. In this article, we review new insights and recent nuclear medicine advances in the management of melanoma patients.

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Section: Lymphoscintigraphy Improves the Accuracy Of Sentinel Lymph Nmentioning

confidence: 99%