Reply to: ‘What is the optimal dose of neurohormonal modulators in patients with heart failure? The higher the better?’

Abstract

Reply to: 'What is the optimal dose of neurohormonal modulators in patients with heart failure? The higher the better?'We thank Xie and coauthors for their interest in our paper on the association between dosing and combination use of medications and outcomes in patients with heart failure and a reduced ejection fraction of the Swedish Heart Failure Registry. 1 We agree that the notion of 'target dose' (TD) might be disputed. However, we would like to clarify that the primary aim of our . .