2006
DOI: 10.1086/504082
|View full text |Cite
|
Sign up to set email alerts
|

Reply to Winston and Shepp and to Lanzafame et al

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2006
2006
2013
2013

Publication Types

Select...
4

Relationship

0
4

Authors

Journals

citations
Cited by 4 publications
(2 citation statements)
references
References 4 publications
0
2
0
Order By: Relevance
“…Our results demonstrate a small but statistically signifi cant loss of renal function in the fi rst 3.5 months after starting a TDF containing regimen. We show that boosted PI augments this effect, possibly due to inhibition of MRP2 (Zimmermann et al, 2006). Raltegravir appears to offer some protection, which has not been shown before, but may be due to competition for the OAT1 infl ux transporter (Moss et al, 2011).…”
Section: Discussionmentioning
confidence: 65%
“…Our results demonstrate a small but statistically signifi cant loss of renal function in the fi rst 3.5 months after starting a TDF containing regimen. We show that boosted PI augments this effect, possibly due to inhibition of MRP2 (Zimmermann et al, 2006). Raltegravir appears to offer some protection, which has not been shown before, but may be due to competition for the OAT1 infl ux transporter (Moss et al, 2011).…”
Section: Discussionmentioning
confidence: 65%
“…Nonetheless, this transient dip could also be real in light of some other observational data, suggesting an initial drop in CL CR on tenofovir, which does not progress with time. 5,10,11 We postulated that due to a lower BW on average, Thai patients should have a higher exposure to tenofovir and might be more likely to develop nephrotoxicity on the standard 300 mg daily dose. However, tenofovir disoproxil fumarate was well tolerated, and significant renal toxicity was not observed.…”
Section: Discussionmentioning
confidence: 99%