Report on Carcinogens Monograph on Haloacetic Acids Found as Water Disinfection By-Products

The National Toxicology Program (NTP) strives to raise awareness of cancer hazards in our environment. Identifying cancer hazards is key to primary prevention, informing public health decision-making, and decreasing the global cancer burden. In December 2021, the U.S. congressionally mandated 15th Report on Carcinogens (RoC) was released, adding eight new substances to the cumulative report. Chronic infection with Helicobacter pylori is listed as ‘known to be a human carcinogen’. Antimony trioxide and six haloacetic acids found as water disinfection byproducts – dichloroacetic acid, dibromoacetic acid, bromochloroacetic acid, tribromoacetic acid, bromodichloroacetic acid, chlorodibromoacetic acid – are each listed as ‘reasonably anticipated to be a human carcinogen’. A new dashboard provides interactive visualization and interrogation of the 256 listed substances, their uses, and associated cancers. Also, NTP recently published a Cancer Hazard Assessment Report on exposure scenarios associated with circadian disruption, concluding that (1) persistent night shift work can cause breast cancer, and (2) certain lighting conditions may cause cancer. As highlighted in these reports and evaluations, we are evolving our approaches to meet contemporary challenges. These approaches include (1) focusing on real-world exposures and (2) advancing our methods to address challenges in cancer hazard assessments, e.g., developing more structured approaches to evaluate mechanistic data and incorporating read-across approaches to assess chemicals lacking adequate human or animal cancer data. To promote public health, we provide information on environmental health disparities and disease prevention. Building on these efforts, we aim to continue our contributions to the “war on cancer”, declared 50 years ago.

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The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them

Smith

Guyton

Kleinstreuer

et al. 2020

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Conflict of Interest Statement: MTS has received consulting fees from attorneys representing plaintiffs in cases involving exposure to benzene, glyphosate and other chemical agents. DWF has received consulting fees from attorneys in cases involving exposure to asbestos, PCBs, TCE and other chemical agents. SM and HL are employees of Amgen. MF was an employee of Amgen during the initial meetings and is currently an employee of Expansion Therapeutics. The other authors declare no competing interests. The views expressed in this publication are those of the authors and do not necessarily represent the decisions, policy or views of their respective institutions. Reference to commercial products or services does not constitute endorsement. Manuscript word count: excluding references, tables and figure 6,883.Figure and tables; Manuscript figures: 1; Manuscript tables: 2

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Report on Carcinogens Monograph on Haloacetic Acids Found as Water Disinfection By-Products

Abstract: Peer review of the draft RoC Monograph on Haloacetic Acids Found as Drinking WaterDisinfection By-products was conducted by an ad hoc expert panel at a public meeting held July 24, 2017, in the Rodbell Auditorium at the

Cited by 4 publications

References 232 publications

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The Key Characteristics of Carcinogens: Relationship to the Hallmarks of Cancer, Relevant Biomarkers, and Assays to Measure Them

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