Report on Three Cases of Advance Ovarian Cancer Upon Bangladeshi Population: Successful Management with Bevacizumab Based Chemotherapy

Abstract

with mutations in the genes BRCA1 or BRCA2 have about a 50% chance of developing the disease. The most common type of ovarian cancer, comprising more than 95% of cases, is ovarian carcinoma 9 . Screening is not recommended in women who are at average risk, as evidence does not support a reduction in death and the high rate of false positive tests may lead to unneeded surgery, which is accompanied by its own risks 10 . Those at very high risk may have their ovaries removed as a preventive measure 5 . If caught and treated in an early stage, ovarian cancer may be curable. Treatment usually includes some combination of surgery, Targeted therapy, radiation therapy, and chemotherapy 5 . Outcomes depend on the extent of the disease and the subtype of the cancer present 9 . The overall fiveyear survival rate in the United States is 45% 11 . Outcomes are worse in the developing world 9 . IntroductionOvarian cancer is a cancer that forms in an ovary 3 . It results in abnormal cells that have the ability to invade or spread to other parts of the body 4 . When this process begins, there may be no or only vague symptoms. Symptoms become more noticeable as the cancer progresses 5,6 . These symptoms may include bloating, pelvic pain, abdominal swelling, and loss of appetite, among others 5 . Common areas to which the cancer may spread include the lining of the abdomen, lining of the bowel and bladder, lymph nodes, lung, and liver 7,8 . The risk of ovarian cancer increases in women who have ovulated more over their lifetime. This includes those who have never had children, those who begin ovulation at a younger age or reach menopause at an older age 9 . Other risk factors include hormone therapy after menopause, fertility medication, and obesity 3 . About 10% of cases are related to inherited genetic risk; women

Risk Factors Of Ovarian Cancer Among The Postmenopausal Women

“…In a survey of 117 cancer patients in Dhaka, 81% had ovarian cancer. The annual mortality rate per 100000 people from ovarian cancer in Bangladesh has increased by 40.3% since 1990, an average of 1.8% a year [21]. OC is a killer of women in high-income countries also.…”