Representation of the visual field in the lateral intraparietal area of macaque monkeys: a quantitative receptive field analysis

Hamed, Suliann Ben; Duhamel, Jean‐René; Bremmer, Frank; Graf, Werner

doi:10.1007/s002210100785

Cited by 227 publications

(242 citation statements)

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“…This finding is consistent with most electrophysiological studies of LIP and with the strong contralateral bias reported in an fMRI study (3,7,27,28; but see ref. 8).…”

Section: Discussionsupporting

confidence: 91%

“…We also found a separate foveal representation in LIPv rostral to the peripheral field map. Previous electrophysiology studies placed the fovea dorsal to the peripheral field representation and concluded that LIP contained a coarse but contiguous retinotopic map of the contralateral field (3,7,14). However, our results are consistent with previous imaging studies reporting a rostral foveal representation (14,21) and with LIP/frontal eye field (FEF) connectivity studies demonstrating that rostral LIP projects to the ventral portion of FEF representing the fovea/parafovea and caudal LIP to the dorsal portion of FEF representing the periphery (2,35,36).…”

Section: Discussionsupporting

confidence: 91%

“…Two electrophysiology studies have reported that LIP has a strong contralateral bias and may be retinotopically organized (3,7). However, the maps in these studies were coarse and not consistent with one another.…”

mentioning

confidence: 89%

“…Although cells throughout LIP appear to play a role in visual and oculomotor processing, the ventral subdivision of the LIP (LIPv) may be more involved in more complex cognitive functions compared with the dorsal subdivision of the LIP (LIPd) (6, 12, 13), and LIPd may be more involved in representing the fovea (3,7,14).…”

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confidence: 99%

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Topographic organization of macaque area LIP

Patel

Shulman

Baker

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Despite several attempts to define retinotopic maps in the macaque lateral intraparietal area (LIP) using histological, electrophysiological, and neuroimaging methods, the degree to which this area is topographically organized remains controversial. We recorded blood oxygenation level-dependent signals with functional MRI from two macaques performing a difficult visual search task on stimuli presented at the fovea or in the periphery of the visual field. The results revealed the presence of a single topographic representation of the contralateral hemifield in the ventral subdivision of the LIP (LIPv) in both hemispheres of both monkeys. Also, a foveal representation was localized in rostral LIPv rather than in dorsal LIP (LIPd) as previous experiments had suggested. Finally, both LIPd and LIPv responded only to contralateral stimuli. In contrast, human studies have reported multiple topographic maps in intraparietal cortex and robust responses to ipsilateral stimuli. These blood oxygenation level-dependent functional MRI results provide clear evidence for the topographic organization of macaque LIP that complements the results of previous electrophysiology studies, and also reveal some unexpected characteristics of this organization that have eluded these previous studies. The results also delineate organizational differences between LIPv and LIPd, providing support for these two histologically defined areas may subserve different visuospatial functions. Finally, these findings point to potential evolutionary differences in functional organization with human posterior parietal cortex.T he macaque lateral intraparietal area (LIP) has been the subject of many investigations over the past few decades. Anatomical studies of this area, which lies on the lateral bank of the intraparietal sulcus (IPS), have demonstrated widespread connectivity with a variety of cortical areas (1-3). Electrophysiological recordings in awake behaving macaques indicate that these connections underlie LIP's role in a range of functions ranging from the planning of saccades to the allocation of attention to the valuation of sensory information (4-6).Despite the many studies of its functional and anatomical properties, the topographic organization of LIP remains controversial. Two electrophysiology studies have reported that LIP has a strong contralateral bias and may be retinotopically organized (3, 7). However, the maps in these studies were coarse and not consistent with one another. In contrast, another study found neither a retinotopic map nor a contralateral-hemifield bias (8). Electrical stimulation studies of LIP have also resulted in an unusual result: in both studies, the sites representing the horizontal meridian lie rostral to those representing both the lower and upper visual fields (9, 10). Thus, the issue of topography in LIP remains an open question.Architectonic studies have divided LIP into dorsal and ventral divisions, but the functional significance of this difference is unclear (3, 11). Although cells throughout LIP appe...

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“…This finding is consistent with most electrophysiological studies of LIP and with the strong contralateral bias reported in an fMRI study (3,7,27,28; but see ref. 8).…”

Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 91%

mentioning

confidence: 89%

mentioning

confidence: 99%

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Topographic organization of macaque area LIP

Patel

Shulman

Baker

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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“…Likewise, we believe it is important to keep in mind that RFs in FEF and LIP have diameters of the order of 10-208 [e.g. 5,6] at eccentricities often used in human psychophysical experiments ( 108). The relevance of such experiments to remapping is questionable unless researchers ensure that stimuli are separated by at least the RF diameter distance.…”

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confidence: 99%

Shifting attention to neurons

Mayo

Sommer

2010

Trends in Cognitive Sciences

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Cavanagh et al.[1] challenge the traditional idea that neuronal activity caused by impending saccades alters receptive field (RF) locations. The authors argue, instead, that saccade-related signals cause shifts of attentional pointers that lack information about object identity but influence visual regions that encode object properties. We agree that the relationship between attention and remapping warrants additional study. However, we think that the authors' proposal, although constructive, is incomplete given neurophysiological data.Attentional allocation and remapping are probably closely related. There is evidence that attention influences the shape of RFs in visual areas MT and V4 [2,3]. A simple extension of this operation might be to move an RF. Also, thinking of remapping as an attention-related process makes sense in terms of timing. Activation transfers caused by an impending eye movement might be too late for some perceptual functions [4], and referencing the transfer to an earlier allocation of attention is an attractive concept.However, three points in the Cavanagh et al. article [1] are problematic. First, some of the ideas regarding RFs are overly simple. The paper generally ignores the fact that points in visual space can be computed from population codes of relatively large RFs and do not necessarily require a huge array of small, retina-like RFs. The computationally intensive model in Figure 2B is therefore unnecessarily elaborate. Likewise, we believe it is important to keep in mind that RFs in FEF and LIP have diameters of the order of 10-208 [e.g. 5, 6] at eccentricities often used in human psychophysical experiments ( 108). The relevance of such experiments to remapping is questionable unless researchers ensure that stimuli are separated by at least the RF diameter distance. Otherwise all stimuli might be contained within a single RF before and after an eye movement, rendering remapping unnecessary.Second, the authors do not provide criteria to help distinguish between the applicability of the presented models. One possible remedy is to provide a provisional, neuron-based account of attentional pointers. Would the authors expect to see representations of attentional pointers in the activity of single neurons within a brain area, in local microcircuits, or in correlated activity as a broader representation across areas? Such basic information would go a long way towards establishing attentional pointers as a testable hypothesis.

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Visual Processing in the Primate Brain

Pasternak

Bisley

Calkins

2003

Handbook of Psychology

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The visual system is the most widely studied and perhaps the best understood mammalian sensory system. Not only have the details of its anatomical features been well described, but the behavior of it neurons have also been characterized at many stages of the neural pathway. This chapter focuses on the visual system of nonhuman primates and deals with the way the primate visual system performs the analysis of various attributes of the visual image and then integrates these attributes into a percept of a visual scene. It shows how such fundamental dimensions of visual stimuli as spatial and temporal variations in luminance and chromaticity are first encoded at the level of the retina, and the manner in which the encoding of other more complex stimulus features, such as motion, complex form and depth, emerge at the level of visual cortex. Finally, modulation of visual cortical activity by such cognitive phenomena as memory and attention are discussed.

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Representation of the visual field in the lateral intraparietal area of macaque monkeys: a quantitative receptive field analysis

Cited by 227 publications

References 60 publications

Topographic organization of macaque area LIP

Topographic organization of macaque area LIP

Shifting attention to neurons

Visual Processing in the Primate Brain

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