2013
DOI: 10.4081/hr.2013.e9
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Repression of Factor VIII Inhibitor Development with Apoptotic Factor VIII-Expressing Embryonic Stem Cells

Abstract: Development of factor VIII (fVIII)-neutralizing antibodies, called inhibitors, is a challenging problem in the management of hemophilia A patients. We explored the possibility of pretreatment with apoptotic fVIII-expressing embryonic stem (ES) cells to prevent the development of fVIII inhibitors. Murine ES cells integrated with the human F8 gene were differentiated into embryoid bodies, dissociated to a single cell suspension, subjected to hypo-osmotic shock to induce apoptosis, and intraperitoneally injected … Show more

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