2009
DOI: 10.1159/000241301
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Reproducibility of Cutaneous Microvascular Function Assessment Using Laser Doppler Flowmetry and Acetylcholine Iontophoresis

Abstract: Aim: To investigate the reproducibility of direct and axon-reflex vasodilator responses to increasing doses of acetylcholine administered transcutaneously by iontophoresis. Methods: Increasing doses of acetylcholine ions were introduced into the skin of the volar forearm with weak electric currents. The elicited vasodilatation was measured with laser Doppler flowmetry at the direct site of acetylcholine administration and approximately 5 mm from this site (within the distribution of axon-reflex vasodilatation)… Show more

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Cited by 11 publications
(10 citation statements)
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“…Direct comparison between LDI reproducibility studies can be very difficult [10] but our findings are in general agreement with previous reproducibility studies undertaken in the upper limbs in normal subjects [10,19] and in patient populations [21] . This suggests that the combined use of LDI and iontophoresis is reproducible, provided the recording sites are standardised and adherence to a protocol is maintained.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Direct comparison between LDI reproducibility studies can be very difficult [10] but our findings are in general agreement with previous reproducibility studies undertaken in the upper limbs in normal subjects [10,19] and in patient populations [21] . This suggests that the combined use of LDI and iontophoresis is reproducible, provided the recording sites are standardised and adherence to a protocol is maintained.…”
Section: Discussionsupporting
confidence: 92%
“…using equipment with different penetration depth), the sites studied (i.e. upper or lower side of forearm [21] ), and the conditions under which reproducibility was tested (i.e. different temperature levels) make meaningful comparisons between studies more difficult [19] .…”
mentioning
confidence: 99%
“…The mean flux measured at both sites over a period of five minutes before stimulation (baseline flux) was used for normalization of data subsequently recorded at the respective site [25-27]. In particular, the automatically recorded table containing data on time and skin blood flow (SkBF) at both sites relative to the underlying stimulation protocol were used.…”
Section: Methodsmentioning
confidence: 99%
“…ACh was much longer lasting than 30 minutes, thus using the same skin site would 10 influence subsequent skin blood flow results; this has been reported previously 11 (Brocx and Drummond, 2009). The order of participants' skin sites tested (lateral vs. 12 medial dorsal foot, third vs. fourth finger) was counter-balanced between 13 participants.…”
mentioning
confidence: 67%