Reproducibility Report for the Paper

Carnà, Stefano

doi:10.1145/3384441.3396228

Proceedings of the 2020 ACM SIGSIM Conference on Principles of Advanced Discrete Simulation 2020

DOI: 10.1145/3384441.3396228

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Reproducibility Report for the Paper

Stefano Carnà

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2022

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Generating Fast Specialized Simulators for Stochastic Reaction Networks via Partial Evaluation

Köster

Warnke

Uhrmacher

2022

ACM Trans. Model. Comput. Simul.

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Domain-specific modeling languages allow a clear separation between simulation model and simulator and, thus, facilitate the development of simulation models and add to the credibility of simulation results. Partial evaluation provides an effective means for efficiently executing models defined in such languages. However, it also implies some challenges of its own. We illustrate this and solutions based on a simple domain-specific language for biochemical reaction networks as well as on the network representation of the established BioNetGen language. We implement different approaches adopting the same simulation algorithms: one generic simulator that parses models at runtime and one generator that produces a simulator specialized to a given model based on partial evaluation and code generation. For the purpose of better understanding, we additionally generate intermediate variants, where only some parts are partially evaluated. Akin to profile-guided optimization, we use dynamic execution of the model to further optimize the simulators. The performance of the approaches is carefully benchmarked using representative models of small to large biochemical reaction networks. The generic simulator achieves a performance similar to state-of-the-art simulators in the domain, whereas the specialized simulator outperforms established simulation tools with a speedup of more than an order of magnitude. Technical limitations in regard to the size of the generated code are discussed and overcome using a combination of link-time optimization and code separation. A detailed performance study is undertaken, investigating how and where partial evaluation has the largest effect.

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Generating Fast Specialized Simulators for Stochastic Reaction Networks via Partial Evaluation

Köster

Warnke

Uhrmacher

2022

ACM Trans. Model. Comput. Simul.

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Reproducibility Report for the Paper

Cited by 1 publication

References 1 publication

Generating Fast Specialized Simulators for Stochastic Reaction Networks via Partial Evaluation

Generating Fast Specialized Simulators for Stochastic Reaction Networks via Partial Evaluation

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