Reproducible Molecularly Imprinted QCM Sensor for Accurate, Stable, and Sensitive Detection of Enrofloxacin Residue in Animal-Derived Foods

Pan, Mingfei; Gu, Ying; Zhang, Miyao; Wang, Junping; Yun, Yaguang; Wang, Shuo

doi:10.1007/s12161-017-1020-1

Cited by 21 publications

(10 citation statements)

References 35 publications

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“…Equation ( 5) can be rearranged to Equation ( 6) [41]. Thus, plotting the frequency shifts obtained for the respective penicillin standards against ∆f Analyte /C Analyte revealed K a and the frequency shift corresponding to the maximum number of binding sites in the MIP (∆f max MIP ): the slope of the curve corresponded to 1/K a and the y-intercept to ∆f MIP (Max) .…”

Section: Mipmentioning

confidence: 99%

Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media

et al. 2021

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Pharmaceuticals wastes have been recognized as emerging pollutants to the environment. Among those, antibiotics in the aquatic environment are one of the major sources of concern, as chronic, low-dose exposure can lead to antibiotic resistance. Herein, we report on molecularly imprinted polymers (MIP) to recognize penicillin V potassium salt (PenV-K), penicillin G potassium salt (PenG-K), and amoxicillin sodium salt (Amo-Na), which belong to the most widespread group of antibiotics worldwide. Characterization and optimization led to two MIPs comprising methacrylic acid as the monomer and roughly 55% ethylene glycol dimethacrylate as the crosslinker. The obtained layers led to sensitive, selective, repeatable, and reusable sensor responses on quartz crystal microbalances (QCM). The LoD for PenV-K, PenG-K, and Amo-Na sensors are 0.25 mM, 0.30 mM, and 0.28 mM, respectively; imprinting factors reach at least around three. Furthermore, the sensors displayed relative selectivity factors of up to 50% among the three penicillins, which is appreciable given their structural similarity.

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Section: Mipmentioning

confidence: 99%

Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media

et al. 2021

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“…Immobilizing pre-prepared MIPs on QCM sensors avoids these problems. This method allows the characteristics of the MIPs to be retained and the MIPs to Sensors 2020, 20, 5506 2 of 13 be removed easily to give the bare QCM sensors [10]. Magnetic MIPs have been developed to avoid the centrifugation and filtration steps required for conventional MIPs [11].…”

Section: Introductionmentioning

confidence: 99%

Magnetic Imprinted Polymer-Based Quartz Crystal Microbalance Sensor for Sensitive Label-Free Detection of Methylene Blue in Groundwater

Xing

et al. 2020

Sensors

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Tiny changes in the mass of the sensor in a quartz crystal microbalance with dissipation monitoring (QCM-D) can be observed. However, the lack of specificity for target species has hindered the use of QCM-D. Here, molecularly imprinted polymers (MIPs) were used to modify a QCM-D sensor to provide specificity. The MIPs were formed in the presence of sodium dodecyl benzene sulfonate. Imprinted layers on Fe3O4 nanoparticles were formed using pyrrole as the functional monomer and cross-linker and methylene blue (MB) as a template. The MIPs produced were then attached to the surface of a QCM-D sensor. The MIPs-coated QCM-D sensor could recognize MB and gave a linear response in the concentration range 25 to 1.5 × 102 µg/L and a detection limit of 1.4 µg/L. The QCM-D sensor was selective for MB over structural analogs. The MIPs-coated QCM-D sensor was successfully used to detect MB in river water and seawater samples, and the recoveries were good. This is the first time MB has been detected using a QCM-D sensor. Mass is an intrinsic property of matter, so this method could easily be extended to other target species by using different MIPs.

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“…[2][3][4][5][6] As a result, ENR is widely used as an antibiotic in livestock farming and aquaculture; however, there are concerns surrounding its use because of its large antimicrobial spectrum. 12,13 Furthermore, ENR is known to have a very long environmental half-life time that can lead to accumulation of significant concentrations in soil and water. [7][8][9][10][11] There is also a risk to the environment, due to the use of the ENR in aquaculture products and its excretion in livestock urine and ordure.…”

Section: Introductionmentioning

confidence: 99%

“…[7][8][9][10][11] There is also a risk to the environment, due to the use of the ENR in aquaculture products and its excretion in livestock urine and ordure. 12,13 Furthermore, ENR is known to have a very long environmental half-life time that can lead to accumulation of significant concentrations in soil and water. 11,12 Several different analytical methods have been reported for the determination of ENR, including capillary electrophoresis, high-performance liquid chromatography, gas chromatography-mass spectrometry, and liquid chromatography-mass spectrometry.…”

Section: Introductionmentioning

confidence: 99%

Preparation of cadmium sulfide nanoparticles and their application for improving the properties of the electrochemical sensor for the determination of enrofloxacin in real samples

Liu

Zhang

2019

Chirality

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An advanced electrochemical sensor for the detection of enrofloxacin (ENR) based on the use of a modified electrode containing cadmium sulfide (CdS) nanoparticles (NPs) is reported. The CdS NPs were synthesized and characterized and then coated onto the electrode to fabricate a modified electrode that exhibited a lower limit of detection of 9.5 × 10 −8 mol·L −1 . This detection limit compares with a traditional electrode that exhibited a concentration detection range of 1.0 × 10 −2 to 1.0 × 10 −7 mol·L −1 . This modified electrode demonstrated good selectivity, reproducibility, response time (<40 s), lifetime (up to 12 wk), and pH range (3.3-7.2) for the determination of ENR in real samples (eg, pig urine).

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Reproducible Molecularly Imprinted QCM Sensor for Accurate, Stable, and Sensitive Detection of Enrofloxacin Residue in Animal-Derived Foods

Cited by 21 publications

References 35 publications

Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media

Development of a MIP-Based QCM Sensor for Selective Detection of Penicillins in Aqueous Media

Magnetic Imprinted Polymer-Based Quartz Crystal Microbalance Sensor for Sensitive Label-Free Detection of Methylene Blue in Groundwater

Preparation of cadmium sulfide nanoparticles and their application for improving the properties of the electrochemical sensor for the determination of enrofloxacin in real samples

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