Reproductive and Developmental Toxicity Study of Gadobenate Dimeglumine Formulation (E7155) (3) : Study of Embryo-Fetal Toxicity in Rabbits by Intravenous Administration

Okuda, Yasuyuki; Sagami, Fumio; Tirone, Piero; Morisetti, Alberto; Bussi, Simona; Masters, Robert E.

doi:10.2131/jts.24.supplementi_79

Cited by 64 publications

(28 citation statements)

References 5 publications

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“…31 Gadolinium crosses the placenta, where it is presumably excreted by the fetal kidneys into the amniotic fluid. In the era of gadolinium-induced nephrogenic systemic fibrosis, this raises theoretical concerns of toxicity related to disassociation and persistence of free gadolinium.…”

Section: Risks Of Gadolinium Use In Pregnancymentioning

confidence: 99%

Guidelines for Computed Tomography and Magnetic Resonance Imaging Use During Pregnancy and Lactation

Chen¹,

Coakley²,

Kaimal

et al. 2008

Obstetrics &Amp; Gynecology

409

235

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There has been a substantial increase in the use of computed tomography (CT) and magnetic resonance imaging (MRI) in pregnancy and lactation. Among some physicians and patients, however, there are misperceptions regarding risks, safety, and appropriate use of these modalities in pregnancy. We have developed a set of evidence-based guidelines for the use of CT, MRI, and contrast media during pregnancy for selected indications including suspected acute appendicitis, pulmonary embolism, renal colic, trauma, and cephalopelvic disproportion. Ultrasonography is the initial modality of choice for suspected appendicitis, but if the ultrasound examination is negative, MRI or CT can be obtained. Computed tomography should be the initial diagnostic imaging modality for suspected pulmonary embolism. Ultrasonography should be the initial study of choice for suspected renal colic. Ultrasonography can be the initial imaging evaluation for trauma, but CT should be performed if serious injury is suspected. Pelvimetry now is used rarely for suspected cephalopelvic disproportion, but when required, low-dose CT pelvimetry can be performed with minimal risk. Although iodinated contrast seems safe to use in pregnancy, intravenous gadolinium is contraindicated and should be used only when absolutely essential. It seems to be safe to continue breast-feeding immediately after receiving iodinated contrast or gadolinium. Although teratogenesis is not a major concern after exposure to prenatal diagnostic radiation, carcinogenesis is a potential risk. When used appropriately, CT and MRI can be valuable tools in imaging pregnant and lactating women; risks and benefits always should be considered and discussed with patients.

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Section: Risks Of Gadolinium Use In Pregnancymentioning

confidence: 99%

Guidelines for Computed Tomography and Magnetic Resonance Imaging Use During Pregnancy and Lactation

Chen¹,

Coakley²,

Kaimal

et al. 2008

Obstetrics &Amp; Gynecology

409

235

View full text Add to dashboard Cite

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“…Magnetic resonance imaging (MRI) is regarded as the modality of choice for acquisition of cross sectional imaging, as no studies to date have demonstrated adverse effects on the fetus from MRI (Figure 1) [5]. Gadolinium, which has been shown to have teratogenic effects in animal models, is not recommended for use during pregnancy [6]. Iodine based contrast should also be avoided during pregnancy.…”

Section: Diagnosismentioning

confidence: 99%

The Management of Lymphoma in the Setting of Pregnancy

Pinnix

Andraos

Milgrom

et al. 2017

Curr Hematol Malig Rep

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The diagnosis of lymphoma in pregnant patients poses a therapeutic challenge necessitating consideration of the developing fetus without compromise of therapy with curative potential for the mother. The decision to initiate therapy during pregnancy is heavily influenced by fetal, maternal and disease related factors, of which the most influential are the trimester at diagnosis, the stage and aggressiveness of the disease and the presence of life threatening symptoms. Recent data suggest that deferral of therapy until after the 1st trimester is desirable if it is perceived that postponement of therapy will not compromise maternal outcome. For some patients delay of therapy to the post-partum period is feasible.

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“…Noncontrast MRI can readily detect most common fetal anomalies, therefore, GBCAs are not widely used in fetal MRI. The toxic effect of gadolinium to the fetus has been adequately tested in animals, but data in humans are still limited [15]. This makes gadolinium a category C medication (the safety in humans has not been proven and the impact of prolonged prenatal use remains unclear).…”

Section: Safety Of Mri Contrast Media During Pregnancymentioning

confidence: 99%

Fetal magnetic resonance imaging and ultrasound

Wataganara

Ebrashy

Aliyu

et al. 2016

Journal of Perinatal Medicine

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Magnetic resonance imaging (MRI) has been increasingly adopted in obstetrics practice in the past three decades. MRI aids prenatal ultrasound and improves diagnostic accuracy for selected maternal and fetal conditions. However, it should be considered only when highquality ultrasound cannot provide certain information that affects the counseling, prenatal intervention, pregnancy course, and delivery plan. Major indications of fetal MRI include, but are not restricted to, morbidly adherent placenta, selected cases of fetal brain anomalies, thoracic lesions (especially in severe congenital diaphragmatic hernia), and soft tissue tumors at head and neck regions of the fetus. For fetal anatomy assessment, a 1.5-Tesla machine with a fast T2-weighted single-shot technique is recommended for image requisition of common fetal abnormalities. Individual judgment needs to be applied when considering usage of a 3-Tesla machine. Gadolinium MRI contrast is not recommended during pregnancy. MRI should be avoided in the first half of pregnancy due to small fetal structures and motion artifacts. Assessment of fetal cerebral cortex can be achieved with MRI in the third trimester. MRI is a viable research tool for noninvasive interrogation of the fetus and the placenta.

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Reproductive and Developmental Toxicity Study of Gadobenate Dimeglumine Formulation (E7155) (3) : Study of Embryo-Fetal Toxicity in Rabbits by Intravenous Administration

Cited by 64 publications

References 5 publications

Guidelines for Computed Tomography and Magnetic Resonance Imaging Use During Pregnancy and Lactation

Guidelines for Computed Tomography and Magnetic Resonance Imaging Use During Pregnancy and Lactation

The Management of Lymphoma in the Setting of Pregnancy

Fetal magnetic resonance imaging and ultrasound

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