Reproductive history patterns and long-term mortality rates: a Danish, population-based record linkage study

Coleman, Priscilla K.; Reardon, David C.; Calhoun, Byron C.

doi:10.1093/eurpub/cks107

Cited by 21 publications

(40 citation statements)

References 7 publications

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“…96 Indeed, given the fact that a disproportionate number of deaths associated with prior pregnancy loss are due to suicide and accidents, it would appear that causal contribution would most likely be indirect and chiefly mediated by psychological effects which are known to occur among women who experience a pregnancy loss. 2 – 10 , 17 – 19 Moreover, the finding that there pregnancy loss has a dose effect on increased risk of death 90 ( Figure 6 ) strongly parallels the finding of pregnancy loss having a dose effect on increased risk of mental illness. 2 , 5 , 13 …”

Section: Discussionsupporting

confidence: 62%

“…The remaining 11 studies met the criteria for the second level of eligibility: reporting results of linkage of death certificates to independent records of pregnancy loss. These included seven studies from Finland, 1 , 83 – 88 two from Denmark, 89 , 90 and two from the United States. 91 , 92 Two of these investigated only deaths in the year following TOP.…”

Section: Resultsmentioning

confidence: 99%

“…TOP associated mortality rates are higher than birth associated mortality during the first 180 days 89 and remains higher for six or more years. 89 , 90 , 92 ( Figure 4 )…”

Section: Resultsmentioning

confidence: 99%

“…There is a dose effect, whereby exposure to multiple pregnancy losses increases the negative effect on life expectancy whereas multiple births increases life expectancy. 90 ( Figure 6 )…”

Section: Resultsmentioning

confidence: 99%

“…This may explain the higher pregnancy loss mortality rate observed in the Finnish data since a significant portion of the Finnish subjects would have been exposed to multiple pregnancy losses for which a dose effect of increased mortality risk has been observed. 90 …”

Section: Discussionmentioning

confidence: 99%

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Pregnancy associated death in record linkage studies relative to delivery, termination of pregnancy, and natural losses: A systematic review with a narrative synthesis and meta-analysis

Reardon¹,

Thorp

2017

SAGE Open Medicine

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Objectives:Measures of pregnancy associated deaths provide important guidance for public health initiatives. Record linkage studies have significantly improved identification of deaths associated with childbirth but relatively few have also examined deaths associated with pregnancy loss even though higher rates of maternal death have been associated with the latter. Following PRISMA guidelines we undertook a systematic review of record linkage studies examining the relative mortality risks associated with pregnancy loss to develop a narrative synthesis, a meta-analysis, and to identify research opportunities.Methods:MEDLINE and SCOPUS were searched in July 2015 using combinations of: mortality, maternal death, record linkage, linked records, pregnancy associated mortality, and pregnancy associated death to identify papers using linkage of death certificates to independent records identifying pregnancy outcomes. Additional studies were identified by examining all citations for relevant studies.Results:Of 989 studies, 11 studies from three countries reported mortality rates associated with termination of pregnancy, miscarriage or failed pregnancy. Within a year of their pregnancy outcomes, women experiencing a pregnancy loss are over twice as likely to die compared to women giving birth. The heightened risk is apparent within 180 days and remains elevated for many years. There is a dose effect, with exposure to each pregnancy loss associated with increasing risk of death. Higher rates of death from suicide, accidents, homicide and some natural causes, such as circulatory diseases, may be from elevated stress and risk taking behaviors.Conclusions:Both miscarriage and termination of pregnancy are markers for reduced life expectancy. This association should inform research and new public health initiatives including screening and interventions for patients exhibiting known risk factors.

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Section: Discussionsupporting

confidence: 62%

Section: Resultsmentioning

confidence: 99%

“…TOP associated mortality rates are higher than birth associated mortality during the first 180 days 89 and remains higher for six or more years. 89 , 90 , 92 ( Figure 4 )…”

Section: Resultsmentioning

confidence: 99%

“…There is a dose effect, whereby exposure to multiple pregnancy losses increases the negative effect on life expectancy whereas multiple births increases life expectancy. 90 ( Figure 6 )…”

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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