Reproductive Outcomes Between Fresh and Freeze Only Deferred Blastocyst Transfers

Abstract

body mass index (BMI) and IVF cycle type (fresh vs frozen embryo transfer). P < 0.05 was considered statistically significant.RESULTS: In the 606 unique patients, the median AMH values among women who had a PTB (n¼39) was 2.5 ng/mL ], compared to 2.7 ng/mL IQR [1.3-5.2] among those who had a term delivery (n¼567) (p¼0.92). Odds of PTB was not significantly different by AMH quartile after adjusting for age, bod and cycle type. Women with AMH in the 2 nd , 3 rd , and 4 th AMH quartiles had an adjusted odds ratio (aOR) for PTB of 0.80 (95% confidence interval (CI): 0.32 -2.01), 0.50 (95% CI 0.18 -1.42) and 1.01 (95% CI 0.41 -2.48), respectively, when compared to the lowest quartile. Among women with PCOS (n¼90), there was no difference in odds of PTB (2 nd quartile -aOR 1.73, 95% CI: 0.26 -11.58; 3 rd quartile -aOR 0.57, (95% CI 0.18 -1.42), 4 th quartile -aOR 1.03; 95% CI 0.12 -8.64) compared to the lowest quartile. No differences were also seen when examining AMH quartiles and prevalence of PTB in fresh (n¼183) and frozen cycles separately (n¼423).CONCLUSIONS: Our study shows that women with elevated AMH were not more likely to experience a spontaneous PTB after IVF than women with lower AMH values. Women with the diagnosis of PCOS were also not more likely to experience a PTB, however the sample size was limited. Larger cohort studies specifically in women with PCOS are needed to understand the relationship between AMH and preterm birth.