Reproductive toxicity and gender differences induced by cadmium telluride quantum dots in an invertebrate model organism

Yan, Siqi; Xing, Rui; Zhou, Yanfeng; Li, Kai-Le; Su, Yuanyuan; Qiu, Jian-Feng; Zhang, Yunhu; Zhang, Ke‐Qin; He, Yao; Luo, Xiaoping; Xu, Shiqiang

doi:10.1038/srep34182

Cited by 29 publications

(20 citation statements)

References 61 publications

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“…The genetic integrity of the gonads is an essential aspect of reproductive success [63]. Thus, as ROS can harm the DNA and cells, this damaged genetic will be inherited to the next generation as the defective genetic [64,65]. In summary, even though the direct evidence that the PS-NPs passed through the bio-barrier and moved to further tissues in fish, such as gonads and brain, could not be shown; the fact that these organs were affected become an indicator from the perspective of biological effects.…”

Section: Reproductive Toxicity Of Ps-npsmentioning

confidence: 99%

Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure

Sarasamma

Audira

Siregar

et al. 2020

IJMS

273

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Plastic pollution is a growing global emergency and it could serve as a geological indicator of the Anthropocene era. Microplastics are potentially more hazardous than macroplastics, as the former can permeate biological membranes. The toxicity of microplastic exposure on humans and aquatic organisms has been documented, but the toxicity and behavioral changes of nanoplastics (NPs) in mammals are scarce. In spite of their small size, nanoplastics have an enormous surface area, which bears the potential to bind even bigger amounts of toxic compounds in comparison to microplastics. Here, we used polystyrene nanoplastics (PS-NPs) (diameter size at ~70 nm) to investigate the neurobehavioral alterations, tissue distribution, accumulation, and specific health risk of nanoplastics in adult zebrafish. The results demonstrated that PS-NPs accumulated in gonads, intestine, liver, and brain with a tissue distribution pattern that was greatly dependent on the size and shape of the NPs particle. Importantly, an analysis of multiple behavior endpoints and different biochemical biomarkers evidenced that PS-NPs exposure induced disturbance of lipid and energy metabolism as well as oxidative stress and tissue accumulation. Pronounced behavior alterations in their locomotion activity, aggressiveness, shoal formation, and predator avoidance behavior were exhibited by the high concentration of the PS-NPs group, along with the dysregulated circadian rhythm locomotion activity after its chronic exposure. Moreover, several important neurotransmitter biomarkers for neurotoxicity investigation were significantly altered after one week of PS-NPs exposure and these significant changes may indicate the potential toxicity from PS-NPs exposure. In addition, after ~1-month incubation, the fluorescence spectroscopy results revealed the accumulation and distribution of PS-NPs across zebrafish tissues, especially in gonads, which would possibly further affect fish reproductive function. Overall, our results provided new evidence for the adverse consequences of PS-NPs-induced behavioral dysregulation and changes at the molecular level that eventually reduce the survival fitness of zebrafish in the ecosystem.

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Section: Reproductive Toxicity Of Ps-npsmentioning

confidence: 99%

Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure

Sarasamma

Audira

Siregar

et al. 2020

IJMS

273

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“…, amide; NM, nanomaterial; NOS, nitric oxide synthase; NeUT, neutrophilic granulocyte count; NP, nanoparticle; nSPs, nanosilica particles; PbS, lead sulfide; PEG-b-PLA, poly(ethylene glycol)-block-poly(d,l-lactic acid); PI, propidium iodide; P4, progesterone; PND, postnatal day; QD, quantum dot; RBC, red blood cell;RIA, radioimmunoassay; RT-PCR, real-time PCR; SD, Sprague Dawley; SOD, superoxide dismutase; SeM, scanning electron microscope; SLGO, single-layer graphene oxide; SSCs, spermatogonial stem cells; tPA, tissue plasminogen activator;T, testosterone; TeM, transmission electron microscopy; wBC, white blood cells; vCL, curvilinear velocity; vSL, straight line velocity.of spermatocysts and ovarioles and in internal germ cells, leading to the induction of early germ cell death or malformations via complex mechanisms related to apoptosis and autophagy through mitochondrial and lysosomal pathways 72. AgNPs cause apoptosis, necrosis, and decreased proliferation and an increase in DNA strand breaks in NT2 cells 73.…”

mentioning

confidence: 99%

Potential adverse effects of nanoparticles on the reproductive system

Wang¹,

Song²,

Wu³

et al. 2018

IJN

175

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With the vigorous development of nanometer-sized materials, nanoproducts are becoming widely used in all aspects of life. In medicine, nanoparticles (NPs) can be used as nanoscopic drug carriers and for nanoimaging technologies. Thus, substantial attention has been paid to the potential risks of NPs. Previous studies have shown that numerous types of NPs are able to pass certain biological barriers and exert toxic effects on crucial organs, such as the brain, liver, and kidney. Only recently, attention has been directed toward the reproductive toxicity of nanomaterials. NPs can pass through the blood–testis barrier, placental barrier, and epithelial barrier, which protect reproductive tissues, and then accumulate in reproductive organs. NP accumulation damages organs (testis, epididymis, ovary, and uterus) by destroying Sertoli cells, Leydig cells, and germ cells, causing reproductive organ dysfunction that adversely affects sperm quality, quantity, morphology, and motility or reduces the number of mature oocytes and disrupts primary and secondary follicular development. In addition, NPs can disrupt the levels of secreted hormones, causing changes in sexual behavior. However, the current review primarily examines toxicological phenomena. The molecular mechanisms involved in NP toxicity to the reproductive system are not fully understood, but possible mechanisms include oxidative stress, apoptosis, inflammation, and genotoxicity. Previous studies have shown that NPs can increase inflammation, oxidative stress, and apoptosis and induce ROS, causing damage at the molecular and genetic levels which results in cytotoxicity. This review provides an understanding of the applications and toxicological effects of NPs on the reproductive system.

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“…The accumulation of QDs in testicular tissue indicated that there was an interaction between QDs and biological barrier, leading to the uptake and distribution of QDs [19]. Yan et al CdTe QDs could pass through the outer membrane of the silkworm's gonad, produce reactive oxygen species (ROS) in membranes of spermatocysts and internal germ cells, and affect the reproductive system [20]. Zhao et al found that the uorescent NPs derived from roasted pork could distribute rapidly in the testis of mice within 24 hours after oral administration [21].…”

Section: Biodistribution Of Cdse/zns Qds In Testesmentioning

confidence: 99%

Systematic evaluation of CdSe/ZnS Quantum Dots toxicity on the reproduction and offspring health in male BALB/c mice

Lin

Chen

et al. 2020

Preprint

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Background: Increased applications of quantum dots (QDs) in biomedical field have aroused attention for their potential toxicological effects. Although many studies have been carried out on the toxicity of QDs, their effects on reproductive and development are still unclear. In this study, we systematically evaluated the male reproductive toxicity and developmental toxicity of CdSe/ZnS QDs in BALB/c mice.Results: The male mice were injected intravenously with CdSe/ZnS QDs at the dosage of 2.5 mg/kg BW or 25 mg/kg BW, respectively, and the survival status, biodistribution of QDs in testes, serum sex hormone levels, histopathology, sperm motility and acrosome integrity was measured on Day 1, 7, 14, 28 and 42 after injection. On Day 35 after treatment, male mice were housed with non-exposed female mice, and then offspring number, body weight, organ index and histopathology of major organs, blood routine and biochemical tests of offspring were measured to evaluate the fertility and offspring health. The results showed that CdSe/ZnS QDs could rapidly distribute in the testis, and the fluorescence of QDs could still be detected on Day 42 post-injection. QDs had no adverse effect on the structure of testis and epididymis, but high-dose QDs could induce apoptosis of Leydig cells in testis at an early stage. No significant differences in survival of state, body weight organ index of testis and epididymis, sex hormones levels, sperm quality, sperm acrosome integrity and fertility of male mice were observed in QDs exposed groups. However, the development of offspring was obviously influenced, which was mainly manifested in the slow growth of offspring, changes of organ index of main organs, and the abnormality of liver and kidney function parameters.Conclusion: Our findings revealed that CdSe/ZnS QDs were able to cross the blood-testis barrier (BTB), produce no discernible toxic effects on the male reproductive system, but could affect the healthy growth of future generations to some extent. In view of the broad application prospect of QDs in biomedical fields, our findings might provide insight into the biological safety evaluation of the reproductive health of QDs.

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Reproductive toxicity and gender differences induced by cadmium telluride quantum dots in an invertebrate model organism

Cited by 29 publications

References 61 publications

Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure

Nanoplastics Cause Neurobehavioral Impairments, Reproductive and Oxidative Damages, and Biomarker Responses in Zebrafish: Throwing up Alarms of Wide Spread Health Risk of Exposure

Potential adverse effects of nanoparticles on the reproductive system

Systematic evaluation of CdSe/ZnS Quantum Dots toxicity on the reproduction and offspring health in male BALB/c mice

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