Requirement for both IL-12 and IFN-γ signaling pathways in optimal IFN-γ production by human T cells

Losana, Giuliana; Rigamonti, L; Borghi, Igor; Assenzio, Barbara; Ariotti, Silvia; Jouanguy, Emmanuelle; Altare, Frédéric; Forni, Guido; Casanova, Jean‐Laurent; Novelli, Francesco

doi:10.1002/1521-4141(200203)32:3<693::aid-immu693>3.0.co;2-q

Cited by 24 publications

(24 citation statements)

References 42 publications

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“…Both patients were treated with a combination therapy of anti-mycobacterial drugs which did not allow complete control of the BCG infection. After identification of the genetic defect [15] and because IL-12 promotes IFN-c production [22], therapy with rIFN-c (Imukin, Boehringer-Ingelheim) was initiated. As described above, both patients reacted with fever and general crisis but also with decreased size and frequency and subsequent colliquation of infected lymph nodes.…”

Section: Genetic and Immunological Analysessupporting

confidence: 86%

Variable outcome of experimental interferon-? therapy of disseminated Bacillus Calmette-Guerin infection in two unrelated interleukin-12R?1-deficient Slovakian children

Ulrichs

Fieschi

Nevická³

et al. 2005

Eur J Pediatr

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Section: Genetic and Immunological Analysessupporting

confidence: 86%

Variable outcome of experimental interferon-? therapy of disseminated Bacillus Calmette-Guerin infection in two unrelated interleukin-12R?1-deficient Slovakian children

Ulrichs

Fieschi

Nevická³

et al. 2005

Eur J Pediatr

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“…Importantly, 84 of these 110 genes were closely correlated with the TCR␤ and -␥ mRNA expression profiles (Table 3), 88 correlated with the induction profiles of MIG, IP-10, or RANTES, which are known to be highly induced by IFN-␥ (21,22), and 79 correlated with sALT levels in all three chimpanzees (Table 3 and Fig. 1).…”

Section: Liver Gene Expression Profiles In Acutely Infectedmentioning

confidence: 83%

Genomic analysis of the host response to hepatitis B virus infection

Wieland

Thimme

Purcell

et al. 2004

Proc. Natl. Acad. Sci. U.S.A.

614

539

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Previous studies in hepatitis B virus (HBV)-infected humans and chimpanzees suggest that control of HBV infection involves the cells, effector functions, and molecular mediators of the immune response. The objective of the current study was to identify, in the liver of acutely HBV-infected chimpanzees, the spectrum of virusinduced and immune response-related genes that regulate the infection. The results demonstrate that HBV does not induce any genes during entry and expansion, suggesting it is a stealth virus early in the infection. In contrast, a large number of T cell-derived IFN-␥-regulated genes are induced in the liver during viral clearance, reflecting the impact of an adaptive T cell response that inhibits viral replication and kills infected cells, thereby terminating the infection.

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“…IFNγ is mainly produced by natural killer cells and type-1 helper and cytotoxic T cells, and induces macrophage activation leading to enhanced anti-microbial activity with IL-12 31,32) . Considering our in vitro experimental scheme using polyclonal T cell activator, activities of type-1 T cells may not be completely suppressed in the veterans exposed to TCDD, in that production of TNFα, another type1-cytokine 33,34) , was not lowered in the veterans in comparison with that of the control group.…”

Section: Discussionmentioning

confidence: 99%

Immunotoxicological Effects of Agent Orange Exposure to the Vietnam War Korean Veterans.

Kim

Park

et al. 2003

INDUSTRIAL HEALTH

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Immunomodulatory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) demonstrated using animals are thymic atrophy, downregulation of cytotoxic T or B lymphocyte differentiation or activation, whereas human immunotoxicities have not been investigated well. This study was undertaken to evaluate overall immunologic spectrum of the Vietnam War Korean veterans exposed to Agent Orange contaminated with TCDD. Quantity of red blood cells, hemoglobin and hematocrit in the veterans suffered from chronic diseases associated with Agent Orange exposure (Veteranspatient group) were decreased in comparison with those of the veterans without the diseases and the age-matched healthy controls, but no differences in leukocyte populations. Plasma IgG levels were lowered in the veterans than the controls, owing to significant decrease in the IgG1 levels. Increase in the IgE levels was observed in the plasma from the veterans. Alteration of T cell-mediated immunity was also resulted from activation of peripheral blood mononuclear cells with polyclonal T cell activators. Production of IFNγ γ γ γ γ, a major cytokine mediating host resistance against infection or tumoregenesis, was lowered in the veterans-patient group. However, production of IL-4 and IL-10, representative cytokines involved with hypersensitivity induction, was enhanced in the patient group. Overall, this study suggests that military service in Vietnam and/or Agent Orange exposure disturbs immune-homeostasis resulting in dysregulation of B and T cell activities.

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Requirement for both IL-12 and IFN-γ signaling pathways in optimal IFN-γ production by human T cells

Cited by 24 publications

References 42 publications

Variable outcome of experimental interferon-? therapy of disseminated Bacillus Calmette-Guerin infection in two unrelated interleukin-12R?1-deficient Slovakian children

Variable outcome of experimental interferon-? therapy of disseminated Bacillus Calmette-Guerin infection in two unrelated interleukin-12R?1-deficient Slovakian children

Genomic analysis of the host response to hepatitis B virus infection

Immunotoxicological Effects of Agent Orange Exposure to the Vietnam War Korean Veterans.

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