Requirement for Solutions with Oncotic Pressure to Release ANF During Blood Volume Expansion in Conscious and Anesthetized Rats

Plasma volumes, blood volumes, and plasma total protein, albumin, and bilirubin concentrations have been determined in rats for 72 h following 20 or 40 mL kg-1 haemodilution with Fluosol-DA or 0.9% NaCl. Haemodilution with 20 mL kg-1 of either haemodiluent had no influence on the measured values. Plasma and blood volumes did not change after Fluosol-DA haemodilution at 40 mL kg-1, but albumin and bilirubin concentrations were decreased for 72 h. Only bilirubin concentrations were decreased for 72 h following haemodilution with 40 mL kg-1 of 0.9% NaCl. It was concluded that changes in a drug's plasma protein binding, and not the plasma or blood volume, are responsible for the reported alterations in a drug's apparent volume of distribution after haemodilution.

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Requirement for Solutions with Oncotic Pressure to Release ANF During Blood Volume Expansion in Conscious and Anesthetized Rats

Cited by 2 publications

References 16 publications

Single injection of pentobarbital induces long-lasting effects on ANP synthesis and gene expression in the rat atria

Single injection of pentobarbital induces long-lasting effects on ANP synthesis and gene expression in the rat atria

Plasma volumes, blood volumes, and plasma protein concentrations after moderate haemodilution with Fluosol-DA or normal saline in the rat

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