Reresection of Colorectal Liver Metastasis with Vena Cava Resection

Tardu, Ali; Kayaalp, Cüneyt; Yilmaz, Sezai; Tolan, Kerem; Ersan, Veysel; Karagül, Servet; Ertuğrul, İlker; Kırmızı, Serdar

doi:10.1155/2016/8173048

Cited by 7 publications

(12 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Individual survival outcomes could be extracted in 126 patients [16,17,[19][20][21][22][23][24]26,27,29,30,[32][33][34][35][36][37]40,41,44]. A Kaplan-Meier analysis showed a median OS of 34 months (confidence interval-CI-: 30-40) (Figure 2), and the 1-year, 3-year, and 5-year OS was 71.4%, 19.8%, and 7.1%, respectively (Table 2).…”

Section: Pathological Oncological and Survival Outcomesmentioning

confidence: 99%

Surgery of Colorectal Liver Metastases Involving the Inferior Vena Cava: A Systematic Review

Serradilla-Martín

Oliver-Guillén²,

Ruíz-Quijano

et al. 2023

Cancers

View full text Add to dashboard Cite

Combined hepatic and inferior vena cava (IVC) resection is the only potentially curative treatment for patients with colorectal liver metastases (CRLM) involving the IVC. Most of the existing data come from case reports or small case series. In this paper, a systematic review based on the PICO strategy was performed in accordance with the PRISMA statement. Papers from January 1980 to December 2022 were searched in Embase, PubMed, and the Cochrane Library databases. Articles considered for inclusion had to present data on simultaneous liver and IVC resection for CRLM and report surgical and/or oncological outcomes. From a total of 1175 articles retrieved, 29, including a total of 188 patients, met the inclusion criteria. The mean age was 58.3 ± 10.8 years. The most frequent techniques used were right hepatectomy ± caudate lobe for hepatic resections (37.8%), lateral clamping (44.8%) for vascular control, and primary closure (56.8%) for IVC repair. The thirty-day mortality reached 4.6%. Tumour relapse was reported in 65.8% of the cases. The median overall survival (OS) was 34 months (with a confidence interval of 30–40 months), and the 1-year, 3-year, and 5-year OS were 71.4%, 19.8%, and 7.1%, respectively. In the absence of prospective randomized studies, which are difficult to perform, IVC resection seems to be safe and feasible.

show abstract

Section: Pathological Oncological and Survival Outcomesmentioning

confidence: 99%

Surgery of Colorectal Liver Metastases Involving the Inferior Vena Cava: A Systematic Review

Serradilla-Martín

Oliver-Guillén²,

Ruíz-Quijano

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…However, sometimes hepatic resections cannot be performed, due to the high number of hepatic metastases or to tumor invasion into the main vascular structures or neighboring organs. 9 …”

Section: Natural History Of the Diseasementioning

confidence: 99%

“…In recent decades, an increase in the life expectancy of patients with colorectal cancer has been achieved, with screening, early diagnosis, novel chemotherapy agents, and improvements in radiotherapy and in surgical techniques. Despite these improvements, poor prognostic factors continue to include the presence of metastasis, disease recurrence, and advanced localized tumors, 9 reporting that one-half of these patients with these risk factors die in the presence of these neoplasms. 10 Colorectal cancer is one of the most common diseases, with approximately one million new cases and 500,000 deaths annually worldwide, the main cause of death being metastasis.…”

Section: Introductionmentioning

confidence: 99%

Hepatic Metastasis from Colorectal Cancer

Valderrama-Treviño

Barrera-Mera

Ceballos-Villalva

et al. 2016

Euroasian Journal of Hepato-Gastroenterology

193

141

View full text Add to dashboard Cite

related to cancer, with a mean average age of 50 years in 75% of cases. 5Mortality rate by age in colorectal cancer is higher in men than in women, and is also twofold in developed (11.6/100,000 habitants) in comparison with developing countries (6.6/100,000 inhabitants), highlighting the region of Eastern Europe, with the highest mortality rate for men and women.Worldwide mortality has increased from 1990 to 2013 (57%); however, in some regions of Europe, North America, and Asia, this has decreased, primarily due to the application of screening methods, such as colonoscopy, which is related with early diagnosis and treatment. 5 ABSTRACTThe liver is the most common site of metastasis in patients with colorectal cancer due to its anatomical situation regarding its portal circulation. About 14 to 18% of patients with colorectal cancer present metastasis at the first medical consultation, and 10 to 25% at the time of the resection of the primary colorectal cancer. The incidence is higher (35%) when a computed tomography (CT) scan is used.In the last decades, a significant increase in the life expectancy of patients with colorectal cancer has been achieved with different diagnostic and treatment programs. Despite these improvements, the presence of metastasis, disease recurrence, and advanced local tumors continue to remain poor prognostic factors.Median survival without treatment is <8 months from the moment of its presentation, and a survival rate at 5 years of 11% is the best prognosis for those who present with local metastasis. Even in patients with limited metastatic disease, 5-year survival is exceptional. Patients with hepatic metastasis of colorectal cancer have a median survival of 5 to 20 months with no treatment. Approximately 20 to 30% of patients with colorectal metastasis have disease confined to the liver, and this can be managed with surgery. Modern surgical strategies at the main hepatobiliary centers have proved that hepatectomy of 70% of the liver can be performed, with a mortality rate of <5%.It is very important to have knowledge of predisposing factors, diagnostic methods, and treatment of hepatic metastasis. However, the establishment of newer, efficient, preventive screening programs for early diagnosis and adequate treatment is vital.

show abstract

“…The metastases of colorectal tumors occur most frequently in the liver, given the location of this organ in relation to the portal circulation (33). The presence of liver metastases is a unanimous negative prognostic factor for colorectal cancer patients (34,35), even more for those operated in emergency.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Prognostic Factors in Complicated Colorectal Cancer Operated in Emergency

Constantin¹,

Firescu²,

Voicu³

et al. 2020

chr

View full text Add to dashboard Cite

Introducere: În anul 2018 cancerul de colon se afla pe locul al 5-lea ca mortalitate prin cancer, iar cancerul rectal pe locul al 10-lea. Supravieţuirea la distanţă a bolnavilor cu cancer colorectal operat în urgenţă, rămâne nesatisfăcătoare, decesul fiind datorat recidivelor locale şi a metastazelor. Scopul: Evaluarea unor corelaţii ale supravieţuirii globale cu caracteristici clinico-paraclinice, tumorale sau de tratament pentru identificarea factorilor de prognostic la pacienţii cu cancer colorectal operat în urgenţă. Material şi Metode: Am efectuat o analiză retrospectivă la 431 pacienţi cu cancer colorectal operat în urgenţă în perioada 2008-2017, cu excluderea celor 40 de pacienţi cu decese postoperatorii, cu o perioadă de urmărire de cel puţin un an. S-au efectuat corelaţii ale unor caracteristici clinico-paraclinice, tumorale sau de tratament cu supravieţuirea globală. Rezultate: În analiza statistic univariată de supravieţuire, se obţine o asociere semnificativă statistic cu: vârsta > 61 ani (p_value = 0.000049), antecedentele chirurgicale abdominal (p_value = 0,031725), bolile cardiace (p_value = 0,000007), fibrilaţia atrială (p_value = 0,007496), diagnosticul la internare (p_value = 0,034352), caşexia (p_value = 0,000000), oligoanuria (p_value = 0,000000), anemia (p_value = 0,000006) dezechilibrul hidroelectrolitic (p_value = 0,000001), localizarea tumorală (p_value = 0,000030), invazia în organele vecine (p_value = 0,000000), aspectul de pelvis îngheţat (p_value = 0,000000), carcinomatoza peritoneală (p_value = 0,000000), metastazele hepatice (p_value=0,000000), tipul de intervenţie chirurgicală (p_value = 0,000000), limfodisecţia (p_value = 0,000001), biopsia hepatică (p_value = 0,043483), reintegrarea tranzitului intestinal (p_value = 0,000000), intervenţiile seriate (p_value = 0,000000), pTNM (p_value = 0,000000), gradingul (p_value = 0,007069). Analiza de regresie multivariată Cox a arătat că: vârsta > 61 ani-HR=1.026, 95%CI(1.012, 1.039) (p_value = 0.000139), caşexia-HR = 1.358, 95%CI(1.046, 1.764) (p_value = 0,021617), carcinomatoza peritoneală-HR = 2.346, 95%CI(1.163, 4.732) (p_value = 0,017253), stadiul bolii-HR=36.745, 95%CI = (14.778, 91.366) (p_ value = 0,000000), tipul de intervenţie-HR = 0.187, 95%CI(0.045, 0.779) (p_ value = 0,021281) şi intervenţiile seriate-HR = 0.282, 95% CI(0.144,0.551) (p_ value = 000213) sunt factori de prognostic independenţi. Concluzii: Factorii de prognostic pentru bolnavii cu cancere colorectale operate în urgenţă sunt: vârsta > 61 ani, prezenţa antecedentelor chirurgicale abdominale şi a tarelor cardiace asociate, în special a fibrilaţiei atriale, diagnosticul de iminenţă de perforaţie diastatică, caşexia, oligoanuria, anemia şi dezechilibrul hidro-electrolitic prezente la internare, tumorile rectale, invazia tumorală în organe vecine, aspectul de "pelvis îngheţat", prezenţa metastazelor hepatice sau a carcinomatozei peritoneale, tumorile nediferenţiate, stadiul III sau IV, practicarea unei derivaţii interne sau neefectuarea limfodisecţiei. Vârsta peste 61 de ...

show abstract

Reresection of Colorectal Liver Metastasis with Vena Cava Resection

Cited by 7 publications

References 8 publications

Surgery of Colorectal Liver Metastases Involving the Inferior Vena Cava: A Systematic Review

Surgery of Colorectal Liver Metastases Involving the Inferior Vena Cava: A Systematic Review

Hepatic Metastasis from Colorectal Cancer

Analysis of Prognostic Factors in Complicated Colorectal Cancer Operated in Emergency

Contact Info

Product

Resources

About