Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator- and apolipoprotein E-conjugated liposomes to the hippocampus

Kuo, Yung‐Chih; Lee, Yin-Jung

doi:10.2147/ijn.s123442

Cited by 20 publications

(7 citation statements)

References 54 publications

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“…NPs could also induce inflammatory factors to inhibit the cell proliferation. 19,29,30 QU-SA-5HTM-PA-PLGA NPs showed lower viability of HBMECs, compared with QU-SA-PA-PLGA NPs and QU-5HTM-PA-PLGA NPs. This could be attributed to SA and 5HTM activity with improved binding and increased membrane transfusion.…”

Section: ■ Results and Discussionmentioning

confidence: 92%

“…The toxicity of QU-SA-5HTM-PA-PLGA NPs could be corroborated from the membrane fusion and subsequent transcellular penetration through HBMECs. NPs could also induce inflammatory factors to inhibit the cell proliferation. ,, QU-SA-5HTM-PA-PLGA NPs showed lower viability of HBMECs, compared with QU-SA-PA-PLGA NPs and QU-5HTM-PA-PLGA NPs. This could be attributed to SA and 5HTM activity with improved binding and increased membrane transfusion.…”

Section: Resultsmentioning

confidence: 94%

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Protection against Neurodegeneration in the Hippocampus Using Sialic Acid- and 5-HT-Moduline-Conjugated Lipopolymer Nanoparticles

Yang

Kuo

Chen

et al. 2019

ACS Biomater. Sci. Eng.

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Significant involvement of oxidative stress in the brain can develop Alzheimer’s disease (AD); however, a great number of clinical trials explains the limited success of antioxidant therapy in dealing with this neurodegenerative disease. Here, we established a lipopolymer system of poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) incorporated with phosphatidic acid (PA) and modified with sialic acid (SA) and 5-hydroxytryptamine-moduline (5HTM) to improve quercetin (QU) activity against oxidative stress induced by amyloid-β (Aβ) deposits. Morphological studies revealed a uniform exterior of QU-SA-5HTM-PA-PLGA NPs with a spherical structure and enhanced aggregation with inclusion of PA in the formulation. A better brain-targeted delivery of the lipopolymeric NPs was verified from the high blood–brain barrier (BBB) permeability of QU through strong interactions of surface SA and 5HTM with O-linked N-acetylglucosamine and 5-HT1B receptors, respectively. Immunofluorescence staining images also supported QU-SA-5HTM-PA-PLGA NPs to traverse the microvessels of AD rat brain. Western blot analysis showed that QU-loaded PA-PLGA NPs suppressed caspase-3 expression. The ability of the nanocarriers to recognize Aβ fibrils was demonstrated from the reduced senile plaque formation and the attenuated acetylcholinesterase and malondialdehyde activity in the hippocampus. Hence, the medication of QU-SA-5HTM-PA-PLGA NPs can facilitate the BBB penetration and prevent Aβ accumulation, lipid peroxidation, and neuronal apoptosis for the AD management.

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Section: ■ Results and Discussionmentioning

confidence: 92%

Section: Resultsmentioning

confidence: 94%

Protection against Neurodegeneration in the Hippocampus Using Sialic Acid- and 5-HT-Moduline-Conjugated Lipopolymer Nanoparticles

Yang

Kuo

Chen

et al. 2019

ACS Biomater. Sci. Eng.

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“…Oral drugs can only partly enter the bloodstream and cannot efficiently enter the encephalon and foci. Considering this issue, Kuo and Lee used serotonin modulators and ApoE-conjugated liposomes, a nanomedicine technique that could build up the nerve growth factor’s BBB permeability, thereby generating neuron anti-apoptosis ( Kuo and Lee, 2016 ). Unfortunately, despite various measures and similar studies, most AD patients die of complications after 5–10 years.…”

Section: Therapeutic Approaches For Alzheimer’s Diseasementioning

confidence: 99%

Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease

Zhou

Zhu

et al. 2022

Front. Neurosci.

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Alzheimer’s disease (AD) has become the most common age-related dementia in the world and is currently incurable. Although many efforts have been made, the underlying mechanisms of AD remain unclear. Extracellular amyloid-beta deposition, intracellular tau hyperphosphorylation, neuronal death, glial cell activation, white matter damage, blood–brain barrier disruption, and other mechanisms all take part in this complicated disease, making it difficult to find an effective therapy. In the study of therapeutic methods, how to restore functional neurons and integrate myelin becomes the main point. In recent years, with the improvement and maturity of induced pluripotent stem cell technology and direct cell reprogramming technology, it has become possible to induce non-neuronal cells, such as fibroblasts or glial cells, directly into neuronal cells in vitro and in vivo. Remarkably, the induced neurons are functional and capable of entering the local neural net. These encouraging results provide a potential new approach for AD therapy. In this review, we summarized the characteristics of AD, the reprogramming technique, and the current research on the application of cellular reprogramming in AD. The existing problems regarding cellular reprogramming and its therapeutic potential for AD were also reviewed.

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“…Cheng et al [ 99 ] developed epigallocatechin-3-gallate (EGCG)-loaded liposomes and demonstrated that the EGCG-loaded liposomes could activate microglia in a rat model of Parkinson’s syndrome in vivo and exert a neuroprotective effect. Kuo et al [ 100 ] prepared serotonin (SM)- and apolipoprotein E (APOE)-modified liposomes and loaded them with nerve growth factor (NGF). The resulting NGF-SM-APOE-LIP liposomes facilitated the passage of NGF through the blood–brain barrier.…”

Section: Lipid-based Delivery Systems In Regenerative Medicinementioning

confidence: 99%

Lipid-Based Drug Delivery Systems in Regenerative Medicine

Filipczak

Yalamarty

et al. 2021

Materials

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The most important goal of regenerative medicine is to repair, restore, and regenerate tissues and organs that have been damaged as a result of an injury, congenital defect or disease, as well as reversing the aging process of the body by utilizing its natural healing potential. Regenerative medicine utilizes products of cell therapy, as well as biomedical or tissue engineering, and is a huge field for development. In regenerative medicine, stem cells and growth factor are mainly used; thus, innovative drug delivery technologies are being studied for improved delivery. Drug delivery systems offer the protection of therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. Similarly, the delivery systems in combination with stem cells offer improvement of cell survival, differentiation, and engraftment. The present review summarizes the significance of biomaterials in tissue engineering and the importance of colloidal drug delivery systems in providing cells with a local environment that enables them to proliferate and differentiate efficiently, resulting in successful tissue regeneration.

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Rescuing cholinergic neurons from apoptotic degeneration by targeting of serotonin modulator- and apolipoprotein E-conjugated liposomes to the hippocampus

Cited by 20 publications

References 54 publications

Protection against Neurodegeneration in the Hippocampus Using Sialic Acid- and 5-HT-Moduline-Conjugated Lipopolymer Nanoparticles

Protection against Neurodegeneration in the Hippocampus Using Sialic Acid- and 5-HT-Moduline-Conjugated Lipopolymer Nanoparticles

Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease

Lipid-Based Drug Delivery Systems in Regenerative Medicine

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