Research advances in the structures and biological activities of secondary metabolites from Talaromyces

Lei, Li-Rong; Gong, Lei-Qiang; Jin, Meng-Ying; Wang, Rui; Liu, Ran; Li, Huang; Wang, Guangzhi; Wang, Dong; Deng, Yun

doi:10.3389/fmicb.2022.984801

Cited by 20 publications

(15 citation statements)

References 85 publications

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“…Talaromyces contains over 200 secondary metabolites, including esters, terpenes, steroids, alkaloids, polyketides, and anthraquinones [ 17 ]. Some compounds have biological activities, such as anti-inflammatory, bacteriostatic, and antitumor activities [ 18 ]. The compounds of Talaromyces sp.…”

Section: Discussionmentioning

confidence: 99%

Talaromyces sp. Ethyl Acetate Crude Extract as Potential Mosquitocide to Control Culex pipiens quinquefasciatus

Chen,

Xu,

Liu

et al. 2023

Molecules

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Vector control is considered an effective approach to controlling diseases spread by mosquito bites. Entomopathogenic fungi are widely used in agriculture to control insect pests, and fungal metabolites can potentially be developed as effective mosquitocides. In this study, a high-throughput screening method was used to search for potential mosquitocides in the Global Fungal Extract Library (GFEL). We tested the larvicidal activity of 264 fungal ethyl acetate crude extracts against Culex pipiens quinquefasciatus. Nine fungal extracts caused moderate to high mortality rates (>50%), with two fungal extracts (58A7 and 101H12) causing a 100% mortality rate. The lethal concentrations for 50% of the population (LC50) were 44.27 mg/L and 31.90 mg/L, respectively. Fraction 14 had a high mortality rate, with an LC50 value of 12.13 mg/L, and was isolated from 58A7 (Fractions 1–11) and 101H12 (Fractions 12–15). Further analyses showed that Fraction 14 was made up of vermistatin and dihydrovermistatin. In a Cx. p. quinquefasciatus larvicidal bioassay, vermistatin (LC50 = 28.13 mg/L) was more toxic than dihydrovermistatin (LC50 = 83.87 mg/L). Our findings suggested that the active fungal extract 101H12 from Talaromyces sp. and its compound vermistatin could be developed as mosquitocides.

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Section: Discussionmentioning

confidence: 99%

Talaromyces sp. Ethyl Acetate Crude Extract as Potential Mosquitocide to Control Culex pipiens quinquefasciatus

Chen,

Xu,

Liu

et al. 2023

Molecules

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“…The fungus Talaromyces , which is broadly dispersed in the natural environment (Zhang K. et al, 2022 ), demonstrates significant potential as a biological resource in food industry, ecology, agriculture, and medicine (Nicoletti et al, 2018 ; Devi et al, 2020 ; Prieto et al, 2021 ; Yadav et al, 2022 ; Aggarwal et al, 2023 ; De Eugenio et al, 2023 ; Xue et al, 2023 ). To further understand its characteristics, the biosynthetic pathways, biological activity (Chen et al, 2022 ; Lei et al, 2022 ; Lv et al, 2023 ; Nicoletti et al, 2023 ), and structure–activity relationship (Xie et al, 2022 ; Zhang M. et al, 2022 ) in Talaromyces have been extensively probed. These studies have also shown that Talaromyces exhibits numerous beneficial bioactivities and exceptional biosynthetic capabilities, which makes it suitable for wide-ranging industrial applications.…”

Section: Introductionmentioning

confidence: 99%

“…The genus Talaromyces has the capability to produce novel secondary metabolites with potent biological activities (Lei et al, 2022 ), such as antimicrobial depsidone (talaronin E) (Nicoletti et al, 2023 ) and polyketide (tanicutone B) (Wang et al, 2023 ), cytotoxic cytochalasan (talachalasin A) (Ding et al, 2023 ), dimeric oxaphenalenone aminoglycoside (glyclauxin D) (Samarasekera et al, 2023 ), antiviral cytochalasan (talachalasin B) (Ding et al, 2023 ), anti-inflammatory α-pyrone derivative (talarolactones E and F) (Li et al, 2023 ), phthalides (amestolkins A and B) (Huang et al, 2023 ), and insecticidal alkaloid (talaroenamine D) (Zang et al, 2015 ). Therefore, Talaromyces can be used to synthesize novel compounds (Kumari et al, 2018 ; Lan and Wu, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35

Cai,

Zhou,

Wang

et al. 2024

Front. Microbiol.

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Six new polyketides, which includes three new lactones (talarotones A–C) (1–3), one new polyketide (talarotide A) (4), two new polyenes (talaroyenes A, B) (5, 6), together with one new meroterpenoid (talaropenoid A) (7) and 13 known compounds (8–20) were isolated from the mangrove-derived fungus Talaromyces flavus TGGP35. The structure and configuration of the compounds 1–7 were elucidated from the data obtained from HR-ESI-MS, IR, 1D/2D NMR spectroscopy, Mo2 (OAc)4-induced electronic circular dichroism (ECD), CD spectroscopy, and modified Mosher's method. Compounds 5 and 20 displayed antioxidant activity with IC50 values of 0.40 and 1.36 mM, respectively. Compounds 3, 6, 11, 16, and 17 displayed cytotoxic activity against human cancer cells Hela, A549, and had IC50 values ranging from 28.89 to 62.23 μM. Compounds 7, 10–12, and 14–18 exhibited moderate or potent anti-insect activity against newly hatched larvae of Helicoverpa armigera Hubner, with IC50 values in the range 50–200 μg/mL. Compound 18 showed antibacterial activity against Ralstonia solanacearum with the MIC value of 50 μg/mL.

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“…Fungi of the genus Talaromyces (Trichocomaceae) are important due not only to their ubiquitous nature, as they can be isolated from soil, plants, marine organisms and foods, but also to their great potential in agricultural applications as biological control agents [ 1 ] and to degrade agricultural waste [ 2 ]. Moreover, Talaromyces species also produce a variety of specialized metabolites such as alkaloids, peptides, polyketides, quinones, steroids and terpenoids, some of which exhibited relevant biological and pharmacological activities [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

New Hybrid Phenalenone Dimer, Highly Conjugated Dihydroxylated C28 Steroid and Azaphilone from the Culture Extract of a Marine Sponge-Associated Fungus, Talaromyces pinophilus KUFA 1767

et al. 2023

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An undescribed hybrid phenalenone dimer, talaropinophilone (3), an unreported azaphilone, 7-epi-pinazaphilone B (4), an unreported phthalide dimer, talaropinophilide (6), and an undescribed 9R,15S-dihydroxy-ergosta-4,6,8 (14)-tetraen-3-one (7) were isolated together with the previously reported bacillisporins A (1) and B (2), an azaphilone derivative, Sch 1385568 (5), 1-deoxyrubralactone (8), acetylquestinol (9), piniterpenoid D (10) and 3,5-dihydroxy-4-methylphthalaldehydic acid (11) from the ethyl acetate extract of the culture of a marine sponge-derived fungus, Talaromyces pinophilus KUFA 1767. The structures of the undescribed compounds were elucidated by 1D and 2D NMR as well as high-resolution mass spectral analyses. The absolute configuration of C-9′ of 1 and 2 was revised to be 9′S using the coupling constant value between C-8′ and C-9′ and was confirmed by ROESY correlations in the case of 2. The absolute configurations of the stereogenic carbons in 7 and 8 were established by X-ray crystallographic analysis. Compounds 1,2, 4–8, 10 and 11 were tested for antibacterial activity against four reference strains, viz. two Gram-positive (Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212) and two Gram-negative (Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853), as well as three multidrug-resistant strains, viz. an extended-spectrum β-lactamase (ESBL)-producing E. coli, a methicillin-resistant S. aureus (MRSA) and a vancomycin-resistant E. faecalis (VRE). However, only 1 and 2 exhibited significant antibacterial activity against both S. aureus ATCC 29213 and MRSA. Moreover, 1 and 2 also significantly inhibited biofilm formation in S. aureus ATCC 29213 at both MIC and 2xMIC concentrations.

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Research advances in the structures and biological activities of secondary metabolites from Talaromyces

Cited by 20 publications

References 85 publications

Talaromyces sp. Ethyl Acetate Crude Extract as Potential Mosquitocide to Control Culex pipiens quinquefasciatus

Talaromyces sp. Ethyl Acetate Crude Extract as Potential Mosquitocide to Control Culex pipiens quinquefasciatus

Bioactive polyketides and meroterpenoids from the mangrove-derived fungus Talaromyces flavus TGGP35

New Hybrid Phenalenone Dimer, Highly Conjugated Dihydroxylated C28 Steroid and Azaphilone from the Culture Extract of a Marine Sponge-Associated Fungus, Talaromyces pinophilus KUFA 1767

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