Research Advances on Hydrogel-Based Materials for Tissue Regeneration and Remineralization in Tooth

Zhang, Zhijun; Bi, Fei; Guo, Weihua

doi:10.3390/gels9030245

Cited by 7 publications

(4 citation statements)

References 128 publications

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“…This unique structure provides hydrogels with flexibility, enabling them to mimic the body’s tissue environment. They offer structural support to the defect site, facilitating repair of bone defects through intrinsic healing mechanisms ( Li et al, 2022b ; Ho et al, 2022 ; Zhang et al, 2023 ). The high water content of hydrogels, similar to the permeability of the extracellular matrix, facilitates the transport of oxygen and nutrients ( Siddiqui et al, 2021 ).…”

Section: Overview Of Hydrogelmentioning

confidence: 99%

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Guo,

Dong,

Wang

2024

Front. Bioeng. Biotechnol.

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Periodontal disease is the most common type of oral disease. Periodontal bone defect is the clinical outcome of advanced periodontal disease, which seriously affects the quality of life of patients. Promoting periodontal tissue regeneration and repairing periodontal bone defects is the ultimate treatment goal for periodontal disease, but the means and methods are very limited. Hydrogels are a class of highly hydrophilic polymer networks, and their good biocompatibility has made them a popular research material in the field of oral medicine in recent years. This paper reviews the current mainstream types and characteristics of hydrogels, and summarizes the relevant basic research on hydrogels in promoting periodontal tissue regeneration and bone defect repair in recent years. The possible mechanisms of action and efficacy evaluation are discussed in depth, and the application prospects are also discussed.

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Section: Overview Of Hydrogelmentioning

confidence: 99%

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Guo,

Dong,

Wang

2024

Front. Bioeng. Biotechnol.

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“…Clinical studies on hydrogels for periodontal applications have been investigated [99]. Hyaluronic acid hydrogels loaded with human fibroblast growth factor 2 were used to treat periodontal defects [20].…”

Section: Clinical Studies On the Application Of Hydrogels For Periodo...mentioning

confidence: 99%

New Insights in Hydrogels for Periodontal Regeneration

Santos,

dos Santos,

Carvalho

2023

JFB

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Periodontitis is a destructive inflammatory disease characterized by microbial infection that damages the tissues supporting the tooth (alveolar bone, gingiva, periodontal ligament, and cementum), ultimately resulting in the loss of teeth. The ultimate goal of periodontal therapy is to achieve the regeneration of all of the periodontal tissues. Thus, tissue engineering approaches have been evolving from simple membranes or grafts to more complex constructs. Hydrogels are highly hydrophilic polymeric networks with the ability to simulate the natural microenvironment of cells. In particular, hydrogels offer several advantages when compared to other forms of scaffolds, such as tissue mimicry and sustained drug delivery. Moreover, hydrogels can maintain a moist environment similar to the oral cavity. Hydrogels allow for precise placement and retention of regenerative materials at the defect site, minimizing the potential for off-target effects and ensuring that the treatment is focused on the specific defect site. As a mechanism of action, the sustained release of drugs presented by hydrogels allows for control of the disease by reducing the inflammation and attracting host cells to the defect site. Several therapeutic agents, such as antibiotics, anti-inflammatory and osteogenic drugs, have been loaded into hydrogels, presenting effective benefits in periodontal health and allowing for sustained drug release. This review discusses the causes and consequences of periodontal disease, as well as the advantages and limitations of current treatments applied in clinics. The main components of hydrogels for periodontal regeneration are discussed focusing on their different characteristics, outcomes, and strategies for drug delivery. Novel methods for the fabrication of hydrogels are highlighted, and clinical studies regarding the periodontal applications of hydrogels are reviewed. Finally, limitations in current research are discussed, and potential future directions are proposed.

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“…The prevalence of oral diseases is a growing concern globally, affecting both developed and developing nations. Typically, oral conditions encompass issues such as dental caries, pulp necrosis, periodontitis, tooth mineralization, and more [ 12 ]. This research aims to develop a hydrogel with enhanced antioxidant capabilities using seagrass extract, therefore incorporating natural compounds into advanced biomaterials designed for dental applications.…”

Section: Introductionmentioning

confidence: 99%

Development of the Antioxidant Property of Seagrass Extract-Based Hydrogel for Dental Application

Sarvesh,

Afeeza,

Suresh

et al. 2024

Cureus

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Background Seagrass is rich in antioxidants, which can help neutralize harmful free radicals in the oral cavity. Free radicals can contribute to oxidative stress, inflammation, and various oral health issues. Incorporating seagrass extract into a hydrogel can enhance its antioxidant capacity, providing a protective effect for oral tissues. The hydrogel, composed of a biocompatible base, ensures that the material is well-tolerated by oral tissue. This is crucial for any dental application to avoid adverse reactions. Aim This work aimed to develop an antioxidant hydrogel that incorporates seagrass extract, with a specific emphasis on its possible use in dentistry. Methods A seagrass sample was collected, and its bioactive compounds were extracted through the utilization of methanol, and subsequent filtration was done. The resulting seagrass filtrate was then integrated into a hydrogel, which was synthesized using polyacrylamide and sodium alginate. Antioxidant hydrogel underwent testing for antioxidant activity through both the 2,2-diphenyl-1-picrylhydrazyl assay and the 2,2′-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) assay. Besides, the hydrogel functional groups were investigated using Fourier transform infrared spectroscopy, while its crystalline structure was examined using X-ray diffraction analysis. Conclusion Seagrass extract provides inherent antioxidant properties, and incorporating this bioactive extract into the hydrogel imparts antioxidant features. The hydrogel's controlled-release property ensures both safety and efficiency. Antioxidant hydrogel for dental applications holds the potential to improve oral health.

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Research Advances on Hydrogel-Based Materials for Tissue Regeneration and Remineralization in Tooth

Cited by 7 publications

References 128 publications

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

Emerging roles of hydrogel in promoting periodontal tissue regeneration and repairing bone defect

New Insights in Hydrogels for Periodontal Regeneration

Development of the Antioxidant Property of Seagrass Extract-Based Hydrogel for Dental Application

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