Research Article Human Serum Paraoxonase (PON-1) and hemochromatosis gene (HFE) gene polymorphisms in occupationally exposed lead workers from Saudi Arabia

Shaik, Abjal Pasha; Alsaeed, Abbas H; Faiyaz-Ul-Haque, Muhammad; Alsaeed, M.A.; Shaik, Asma Sultana

doi:10.4238/gmr18317

Cited by 2 publications

(2 citation statements)

References 22 publications

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“…Polymorphisms in a range of iron metabolism mediators have been linked to differences in lead susceptibility (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

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Levels of Lead in Residential Drinking Water and Iron Deficiency among Patients with End Stage Kidney Disease

Danziger¹,

Mukamal²

2022

Kidney360

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Background: While those with kidney disease may have heightened susceptibility to heavy metal toxicity, whether low levels of drinking water lead contamination have clinical consequence is unknown. Methods: Given that lead toxicity is known to associate with iron deficiency, we merged data from the Environmental Protection Agency (EPA) Safe Drinking Water Information and United States Renal Data Systems to examine whether municipal 90th percentile drinking water lead levels associate with iron deficiency among incident dialysis patients. Iron deficiency was defined across thresholds of transferrin saturation (<10% and 20%) and ferritin (<100 and <200 ng/ml), and simultaneous transferrin saturation <20% and ferritin <200 ng/ml, all obtained within 30 days of dialysis initiation. The average 90th percentile of drinking water lead samples per patient city of residence over a five-year period prior to dialysis initiation were examined at the <1 mcg/L level of detection, and at the 25th, 50th, and 100th percentile of the EPA's actionable level (15 mcg/L). Results: Among 143,754 incident ESKD patients, those in cities with drinking water lead contamination had a 1.06(95%CI 1.03-1.09), 1.06(95%CI 1.02-1.10), and 1.07(95%CI 1.03-1.11) higher adjusted odds of a transferrin saturation <20%, ferritin <200 ng/ml, and simultaneous transferrin saturation <20% and ferritin <200 ng/ml, respectively. These associations were apparent across the range of lead levels found commonly in the United States, and were significantly greater among African American patients (multiplicative interaction p values between lead and race <0.05). Conclusion: Even exposure to low levels of lead contamination, as commonly found in United States drinking water, may have adverse hematologic consequence in patients with advanced kidney disease. These associations are particularly evident amongst African Americans, and while consistent with other environmental injustices facing minorities in the United States, might reflect a greater susceptibility to lead intoxication.

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“…Polymorphisms in a range of iron metabolism mediators have been linked to differences in lead susceptibility (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

“…Although there are known determinants of hepcidin activity, including inflammation, iron, and erythropoietin, whether it is modulated by lead has not been examined (23). Polymorphisms in a range of iron metabolism mediators have been linked to differences in lead susceptibility (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Levels of Lead in Residential Drinking Water and Iron Deficiency among Patients with End Stage Kidney Disease

Danziger¹,

Mukamal²

2022

Kidney360

View full text Add to dashboard Cite

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Occupational health in the Gulf Cooperation Council (GCC): A systematic review and call for comprehensive policy development

Masood,

Khaled,

Bin-Ismail

et al. 2024

PLoS ONE

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Background This systematic review evaluates occupational health within the Gulf Cooperation Council (GCC) countries, focusing on ergonomic, physical, chemical, and biological hazards. It identifies significant impacts of these hazards across various professions and underscores the highlights for region-specific strategies and further research. Methods A comprehensive search in Scopus, PubMed, and Web of Science databases until October 2023 targeted occupational health studies in the GCC, adhering to PRISMA guidelines and NIH Quality Assessment Tools. The protocol was registered on PROSPERO (CRD42023465909). Results From 2202 articles screened, 202 were included, with publications distributed as follows: Saudi Arabia (121), United Arab Emirates (26), Kuwait (20), Oman (15), Qatar (13), and Bahrain (7). Findings indicate that ergonomic hazards, characterized by musculoskeletal disorders, are influenced by job roles and work environments. Physical hazards, particularly needlestick injuries, eye safety concerns, and risks from extreme temperatures and radiation, were notable across the region. Chemical hazards, including exposure to pesticides, cement, and petrochemicals, were identified as significant health risks, necessitating better safety measures. Biological hazards, evidenced in studies from Oman, UAE, and Saudi Arabia, highlighted the risks from infectious agents and parasites, stressing the need for effective prevention and hygiene practices. Conclusion The review advocates for the urgent development of comprehensive health policies to mitigate occupational hazards in the GCC. It highlights the need for collaborative efforts to address ergonomic challenges, enhance protective measures, and respond to chemical and biological risks effectively. Region-specific strategies, ongoing research, and technological advancements are crucial for ensuring workforce safety in these evolving environments.

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Research Article Human Serum Paraoxonase (PON-1) and hemochromatosis gene (HFE) gene polymorphisms in occupationally exposed lead workers from Saudi Arabia

Cited by 2 publications

References 22 publications

Levels of Lead in Residential Drinking Water and Iron Deficiency among Patients with End Stage Kidney Disease

Levels of Lead in Residential Drinking Water and Iron Deficiency among Patients with End Stage Kidney Disease

Occupational health in the Gulf Cooperation Council (GCC): A systematic review and call for comprehensive policy development

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