2017
DOI: 10.4238/gmr16039045
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Research Article Mac-1 deficiency induces respiratory failure by affecting type I alveolar epithelial cells.

Abstract: ABSTRACT. As a b2 integrin family member, Mac-1 plays an important role in the inflammatory response. Inflammation and lung injury are closely associated, but the involvement of Mac-1 in the occurrence and development of such pathologies remains poorly understood. We aimed to investigate the relationship between Mac-1 deficiency and respiratory failure in Mac-1 knockout {Mac-1 -/-} mice, using C57BL/6J mice as a control. The newborn survival rate of Mac-1 -/-mice was calculated, and mouse lung tissue was treat… Show more

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