Research Communication: A Buckwheat Protein Product Suppresses 1,2-Dimethylhydrazine–Induced Colon Carcinogenesis in Rats by Reducing Cell Proliferation

Liu, Zhihe; Ishikawa, Wakako; Huang, Xuxin; Tomotake, Hiroyuki; Kayashita, Jun; Watanabe, Haruo; Katô, Norihisa

doi:10.1093/jn/131.6.1850

Cited by 90 publications

(49 citation statements)

References 23 publications

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“…Buckwheat proteins products (BWP) are acknowledged as preventive nutrients (Liu et al 2001). They are also associated with the suppression of colon carcinogenesis by reducing cell proliferation, and with the suppression of mammary carcinogenesis by lowering serum estradiol.…”

Section: Dietary and Prophylactic Value Of Buckwheat Grains Or Productsmentioning

confidence: 99%

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Buckwheat grains and buckwheat products - nutritional and prophylactic value of their components - a review

Christa¹,

2008

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Christa K., Soral-Śmietana M. (2008): Buckwheat grains and buckwheat products -nutritional and prophylactic value of their components -a review. Czech J. Food Sci., 26: 153-162.Buckwheat is introduced into the diet as an alternative crop of renewed interest due to its nutritive and healthpromoting value. Experiments with animal models have demonstrated that buckwheat flour may alleviate diabetes, obesity, hypertension, and hypercholesterolemia. A number of nutraceutical compounds exist in buckwheat grains and other tissues. These are a rich source of starch, proteins, antioxidants, and dietary fibre as well as trace elements. The biological value (BV) of buckwheat proteins is comparable to BV of other protein sources. Besides high-quality proteins, buckwheat grains contain some components with prophylactic value: flavonoids, fagopyrins, or thiaminbinding proteins. For the food industry, buckwheat grains are a valuable raw material to be used for the production of functional foods. Buckwheat flour may be a valuable and important ingredient in diets or food products, taking into consideration its nutritive value and potential promotion of human health.

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Section: Dietary and Prophylactic Value Of Buckwheat Grains Or Productsmentioning

confidence: 99%

“…The amino acid composition of buckwheat proteins is well balanced and of a high biological value , although the protein digestibility is relatively low (Liu et al 2001). Buckwheat grains are an important source of microelements, such as: Zn, Cu, Mn, Se (Stibilj et al 2004), and macroelements: K, Na, Ca, Mg (Wei et al 2003).…”

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confidence: 99%

Buckwheat grains and buckwheat products - nutritional and prophylactic value of their components - a review

Christa¹,

2008

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“…Buckwheat seeds are richer in protein compared with rice and wheat. Buckwheat protein improves health in various ways, notably reducing serum cholesterol (Kayashita et al 1995), suppressing gallstones and tumors (Tomotake et al 2000;Liu et al 2001), and inhibiting the angiotensin I-converting enzyme (Ma et al 2006). Moreover, buckwheat is the only cereal that contains rutin, hence it is a beneficial source of this flavonoid (Holasova et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Changes in phenols contents from buckwheat sprouts during growth stage

Koyama

Nakamura

2011

J Food Sci Technol

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Germinated buckwheat is buckwheat seeds soaked in water just until it begins to bud. Buckwheat sprouts are seedling plants of buckwheat grown up to 10-15 cm. The purpose of this study was to determine the optimal growth period for accumulating the most abundant functional phenol(s) in germinated buckwheat that had been soaked in darkness and buckwheat sprouts cultivated by hydroponic culture. The rutin contained in germinated buckwheat was analyzed by CE (capillary electrophoresis). Phenols, including isoorientin, orientin, isovitexin, vitexin, and rutin were separated from buckwheat sprouts by HPLC and identified by LC-MS. The highest rutin content in germinated buckwheat was found to be 15.8 mg/100 g DW at 20 h after germination. Buckwheat sprouts contained five kinds of major phenols. The highest amounts of isoorientin, orientin, isovitexin, and vitexin were measured at day 3, with the exception of rutin, and then a gradual decrease was observed as the sprouts grew. The quantities of isoorientin, orientin, isovitexin, and vitexin at day 3 were 5.8, 11.7, 26.2, and 28.9 mg/100 g FW, respectively. The rutin content rapidly increased to 109.0 mg/100 g FW until day 6. The highest total phenols in buckwheat sprouts were 162.9 mg/100 g FW at day 6. Germinated buckwheat soaked for 20 h and buckwheat sprouts cultivated for 6 days were rich in dietary phenol(s), which makes these plants a valuable functional food for human consumption.

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“…Due to containing nutritional ingredients with high biological value it is an important food source for animal and human consumption. Moreover, diets that contain buckwheat have been linked to many health-benefi cial effects such as: lowered risk of developing high cholesterol and blood pressure, less progression in stenosis and atherosclerosis, protection against breast and other hormone-dependent cancers as well as heart disease and diabetes [5][6][7][8]. The buckwheat's lipid-lowering activity is largely due to its rich supply of fl avonoids, particularly rutin.…”

Section: Introductionmentioning

confidence: 99%

Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids

et al. 2015

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The aim of our study was to stablish the possible alternations in fatty acid composition of brain phospholipids in rats on a standard and high-fat diet supplemented with buckwheat leaf and fl ower mixture (BLF) and subsequent possible benefi cial effects of BLF. Four months old male Wistar rats were randomly divided into fi ve experimental groups fed a standard diet, standard diet supplemented with 5% BLF, high-fat diet, high-fat diet with full-period (13 weeks) of 5% BLF supplementation and high-fat diet with partial-period (7 weeks) of 5% BLF supplementation. Gas-liquid chromatography was performed to analyze the fatty acids in hexane lipid extracts of whole rat brains.Supplementation with BLF did not induce signifi cant changes in fatty acid composition of whole brain phospholipids in rats fed the standard diet. In rats on high-fat diet concomitant (full-period) BLF supplementation increased eicosapentaenoic acid (20:5n-3, EPA), total n-6 and n-6/n-3 ratio, and decreased the percentage of oleic acid (18:1n-9) and estimated activity of Δ-9 desaturase. When BLF application was postponed (partial-period) in the case of developed hyperlipidemia, a decrease of stearic acid (18:0) accompanied with an increased estimated Δ-9 desaturase activity was observed. Regardless of BLF supplementation all high-fat diet-fed groups showed an elevated percentage of linoleic acid (18:2n-6, LA) and a reduced estimated Δ-6 desaturase activity.BLF contributes to the maintenance of stable fatty acid composition of brain phospholipids and supports normal brain function in high-fat diet rats, with more positive effects when BLF was applied before hyperlipidemia developed. This could be the mode of buckwheat health benefi cial effects on the brain.

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Research Communication: A Buckwheat Protein Product Suppresses 1,2-Dimethylhydrazine–Induced Colon Carcinogenesis in Rats by Reducing Cell Proliferation

Cited by 90 publications

References 23 publications

Buckwheat grains and buckwheat products - nutritional and prophylactic value of their components - a review

Buckwheat grains and buckwheat products - nutritional and prophylactic value of their components - a review

Changes in phenols contents from buckwheat sprouts during growth stage

Effects Of Dietary Supplementation With A Mixture Of Buckwheat Leaf And Flower On Fatty Acid Composition Of Rat Brain Phospholipids

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