Research Influence Biological Active Agents in the Course of Regulation of Functional Activity of Platelets and System of a Haemostasis

Abstract

It is shown that the flavonoid pulikarin suppresses activity of an adenylate cyclase and reduces level intracellular [Ca 2+ ], perhaps its effect is connected with inhibition of a gain of cytoplasmatic Ca 2+ as at the expense of its entrance outside, and release from intracellular storages. Perhaps, oppression of fluorescence of membrane-bound Ca 2+ is connected with inhibition of a pulikarin of release of calcium from intracellular depots. The inhibiting effect of a pulikarin on ADP-induced aggregation of platelets is connected with oppression of a gain of cytoplasmatic concentration of Ca 2+ from depot of platelets.

The Effect of Sulphated Cellulose on Haemostasis

“…Тo evaluate the effectiveness of the anticoagulants in practice, clinics have used the rate of double the plasma clotting time or human blood counts in some coagulant tests compared with the readings before drug administration (Ng et al, 2003). In vitro, we showed that the effective concentrations of the studied compounds (APTT, PT, TT, ReaClot) decreased with an increase in the degree of sulphation; similar findings for sulphates of polysaccharides from various types of vegetation have been found in multiple works (Almedia-Lima et al, 2010;Nasirov et al, 2020;Cipriani et al, 2009;Nadjimova et al, 2020;Khoshimov et al, 2015;Luo et al, 2013;Maas et al, 2012;Silva et al, 2012).…”