Research Into One-Step Three Component Reaction of Some Ylidenecyanoacetamides (Or Ylidenemalononitriles), Malononitrile and 1,3-Diaminopropane

Abstract

The one-step interaction of substituted ylidenecyanoacetamides (or ylidenemalononitriles), malononitrile and 1,3-diaminopropane was carried out in methanol environment at room temperature and it established the formation of new substituted dihydropyridopyrimidine derivatives. It also revealed that under the same conditions through the use of one-step threecomponent reaction of pyridylidenecyanoacetamide (or pyridylidenemalononitrile), 2-chloro-5nitrobenzylidenecyanoacetamide (or 2-chloro-5-nitrobenzylidenemalononitrile), 2,6dichlorobenzylidenecyanoacetamide (or 2,6-dichlorobenzylidenemalononitrile), malononitrile and 1,3-diaminopropane there formed substituted derivatives not of dihydropyridopyrimidine but tetrahydropyridopyrimidine. Structures of all synthesized compounds were verified by NMR and X-Ray spectroscopy.

Crystal structure and Hirshfeld surface analysis of 6-amino-8-phenyl-1,3,4,8-tetrahydro-2H-pyrido[1,2-a]pyrimidine-7,9-dicarbonitrile

“…As part of our ongoing studies in this area (Naghiyev et al, 2021), we now report the crystal structure and Hirshfeld surface analysis of the title compound, C 16 H 15 N 5 (I), obtained by a three-component synthesis (Naghiyev, 2019).…”

“…The title compound was synthesized using our previously reported procedure (Naghiyev, 2019), and colourless prisms were obtained upon recrystallization from methanol solution. Table 1 Hydrogen-bond geometry (Å , ).…”