Research Into Sorbtion Properties and Structures of Polymer Hydrogel Immobilized by Doxorubicin

Abstract

The sorption of doxorubicin by hydrogeles obtained through cross-limking of polyacrylic acid with varied quantity (%, mass) of N, N-methylene-bis-acrylamide within pH = 1÷10 interval for 24 hours was performed. It revealed that protonation of active functional groups of hydrogel in acidic media (pH ≤ 4) impedes electrostatic interaction with identical charges in hydrogel and doxorubicin. A small degree of swelling at low pH of medium also impedes the penetration of molecule of antibiotic into internal pores of hydrogele. Note that pH changes toward alkaline medium, deprotonation and thereby negative charging of hydrogele surface leads to the sorption of positively charged molecule of doxorubicin. As the pH changes to the alkaline, the deprotonation of the hydrogel surface and, on the contrary, the negative loading that causes the easy sorption of positively charged doxorubicin molecule..On the other hand, the high swelling of hydrogel in alkaline medium also contributes to the increase of sorption level. Also, the nature of chemical interaction between hydrogel and antibiotic was examined by infrared spectroscopy methods, as well as by scanning electron microscopy. It found that the relation between the polymer and the doxorubicin occurs mainly due to hydrogen bond, electrostatic and hydrophobic interaction.

Study of Sorbsion Properties of Copper (Ii) Ion With Chitosan Based Sorbent

“…It is known that the main factor influencing the sorption of organic and inorganic ions by the adsorbent from aqueous solutions is the pH of the medium. Because the H + and OHions in the solution cause the adsorbent, surface and volume to become charged, ie ionized, which directly affects the sorption rate and sorption capacity of the sorbate [23,24]. In this regard, copper (II) ion were sorbed with Cs sorbent at different pH, sorption capacity (SC) and sorption degree (SD) were calculated according to the following formula ( 1), (2).…”

Immobilization of Levothyroxine in Quaternized N,n-Dietyl N-Methyl Chitosan Hydrogel and Chemical Nature of the Interaction

“…In recent years, the Nagiyev Institute of Catalysis and Inorganic Chemistry of ANAS carries out a lot of research work on the synthesis and investigation of polymer nanogels for immobilization and targeted delivery of biologically active substances and drugs [4][5][6][7][8][9][10][11][12][13]. Among these of particular importance is the work on the synthesis and application of polymer vectors to maintain the long-term biological activity of the thyroid hormone substitute levothyroxine in the organism.…”

RESEARCH INTO KINETIC REGULARITIES OF CATALYTIC LIQUID-PHASE OXIDATION OF n-HEXADECANE IN THE PRESENCE OF METALCOMPLEXES CALALYSTS

“…It is well-known, that polymers containing functional groups as the bearers are widely used for immobilization the number of complex-making sorbents, catalysts and biologically active substances [1][2][3]. The catalytic properties of such metal-polymer complexes were studied in the oxidation reactions of some paraffins and cycloparaffins and it was revealed, that they are higheffective catalyst [4,5].…”