Research on Concanavalin A Crystallization in a Flow-Free Droplet-Based Device

Abstract

Abstract. Protein crystallography is a very critical process that limits the development of pharmaceutical engineering. Microfluidic technology has provided an opportunity for protein crystallization. In this paper, a flow-free droplet-based device is presented for producing highly controlled crystals and fabrication of this device with polydimethylsiloxane (PDMS) is presented. The experiment was performed on the device and shows that the crystals of Con A and protein ligand (DK3) have a spherical structure.