The pace of technological development, including smart factories within Industry 4.0/5.0, means that the vagaries of supply chains observed previously cannot be repeated. The automation and computerization of supply chains, asset tracking, simulation, and the prediction of disruption through artificial intelligence (AI) are becoming a matter of course. In selected countries, this will be facilitated by sixth-generation mobile networks planned for full deployment in 2030. The 6G-based intelligent supply chain management within the Industry 4.0/5.0 paradigm will ensure not only greater fluidity of supply, but also faster response to changes in market availability or prices, allowing substitutes to be found and taken into account in the production process and its logistical provisioning. The article outlines key research and development trends in this area and identifies priority development directions, taking into account the advantages and opportunities offered by the Industrial Internet of Things (IIoT) and machine learning (ML). The emergence of 6G technology will transform the supply chain with unprecedented speed, connectivity, and efficiency. This technology will improve visibility, automation, and collaboration while supporting sustainable and safe operations. As a result, companies will be able to design, plan, and operate their supply chains with greater precision, flexibility, and responsiveness, ultimately leading to a more robust and agile supply chain ecosystem.