Research progress and insights on the role of ferroptosis in wound healing

Abstract

Ferroptosis is a newly discovered cell death type which is different from apoptosis, autophagy, pyroptosis as well as necrosis in the following aspects: morphology, biochemistry, gene and regulatory mechanisms. Ferroptosis is regulated by multiples of mechanisms such as system Xc À mechanism, glutathione peroxidase 4 (GPX4) mechanism, iron metabolism and lipid metabolism. Currently, ferroptosis has been revealed to be significant in wound healing such as diabetic wound, irradiated wound and ultraviolet (UV)-driven wound. Hence, how to intervene in the pathogenesis as well as the development of wounds and promote the wound healing by the regulation of ferroptosis have become a research hotspot. This review systematically summarises the latest scientific advances of ferroptosis and wound healing fields, with hoping to propose a new insight and advance in the wound treatment.biomaterials, diabetic wound, ferroptosis, iron metabolism, lipid peroxidation, wound healing Key Messages• ferroptosis is a newly discovered cell death type which has been revealed to be significant in wound healing such as diabetic wound, irradiated wound and UV-driven wound • we summarised the latest scientific advances of ferroptosis and wound healing fields, with hoping to propose a new insight and advance in the wound treatment

Hesperetin promotes diabetic wound healing by inhibiting ferroptosis through the activation of SIRT3

“…Ferroptosis, distinct from apoptosis, has emerged as a promising therapeutic target for DW treatment (Bi et al, 2023;Gao et al, 2018). Network pharmacology, a field that investigates the pharmacological actions of drugs within biological networks to elucidate their connections with drug constituents, targets, and diseases, offers a novel approach to investigating the biological impacts of small molecules sourced from diverse natural origins (Luo et al, 2020).…”

“…Despite numerous recent efforts to prevent or enhance the healing of DW, progress in addressing delayed wound healing remains sluggish. Ferroptosis, distinct from apoptosis, has emerged as a promising therapeutic target for DW treatment (Bi et al, 2023; Gao et al, 2018).…”

Recent advances in molecular mechanisms of skin wound healing and its treatments

“…There is a strong correlation between ferroptosis and skin wounds ( 136 ). Multiple investigations have shown that the use of ferroptosis inhibitors may enhance the healing of diabetic wounds by suppressing the process of ferroptosis.…”

“…This process can be suppressed by ferrostatin-1. In addition, an overabundance of UV radiation may lead to a deficiency in GSH, which in turn disrupts the balance of redox reactions in the body ( Figure 4 ) ( 136 , 141 ).…”

Anti-Ferroptotic Effect of Cannabidiol in Human Skin Keratinocytes Characterized by Data-Independent Acquisition-Based Proteomics

“…Ferroptosis in skin cells can be induced by environmental stressors (e.g., ultraviolet radiation and air pollution) and internal chemical toxins. Reported studies suggest that ferroptosis is linked to several skin disorders including photoaging, skin wounds, and psoriatic inflammation. − Thus, ferroptosis inhibitors are of research interest for the development of interventions for skin ailments. Our group has investigated natural products for their skin protective effects. − This led to the identification of cannabidiol (CBD), a nonpsychedelic phytocannabinoid, as a natural product with promising biological activities including antioxidant and anti-inflammatory effects.…”