Research progress and perspective in metabolism and metabolomics of psoriasis

Abstract

Psoriasis is considered a systemic disease associated with metabolic abnormalities, and it is important to understand the mechanisms by which metabolism affects pathophysiological processes both holistically and systematically. Metabolites are closely related to disease phenotypes, especially in systemic diseases under multifactorial modulation. The emergence of metabolomics has provided information regarding metabolite changes in lesions and circulation and deepened our understanding of the association between metabolic reprogramming and psoriasis. Metabolomics has great potential for the development of effective biomarkers for clinical diagnosis, therapeutic monitoring, prediction of the efficacy of psoriasis management, and further discovery of new metabolism-based therapeutic targets.

Metabolomics: An Emerging Approach to Understand Pathogenesis and to Assess Diagnosis and Response to Treatment in Spondyloarthritis

“…In the last decade, few metabolomic studies concerning PsA have been published. Most of the research was indeed focused on psoriasis (PsO) [48]. The two diseases share a common background but present specific features at different levels, such as genetics, transcriptomics and proteomics.…”

PPARdelta in Affected Atopic Dermatitis and Psoriasis: A Possible Role in Metabolic Reprograming

“…However, PPARδ can also be envisaged as a key regulator of metabolism, especially in the metabolic shift toward anaerobic glycolysis that has been recently evidenced in psoriatic and atopic lesions [38,79,80]. The production of lactate is largely increased in the epidermis of flaky tail mice and mice treated with MC903, two mouse models of lesional atopic dermatitis [38] and of mice treated with imiquimod, a mouse model of psoriasis [81].…”

Association of the characteristics of the blood metabolome and gut microbiome with the outcome of methotrexate therapy in psoriasis

“…Many studies have included metabolomic analyses of various types of samples (peripheral blood, skin lesions, and urine) from patients with psoriasis and described changes in carbohydrates, lipids, amino acids, and nucleotides ( 5 ). Given that psoriasis is a systemic disease, metabolomics based on peripheral blood can provide an overall picture of the relationship between psoriasis and metabolic pathways in the body.…”