Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products

Yang, Kailin; Zeng, Liuting; Zeng, Jinsong; Deng, Ying; Wang, Shanshan; Xu, Hao; He, Qi; Yuan, Mengxia; Luo, Yanfang; Ge, Anqi; Ge, Jinwen

doi:10.1016/j.arr.2023.102063

Cited by 12 publications

(4 citation statements)

References 295 publications

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“…This meta-analysis demonstrated that NBP is safe and effective in improving motor symptoms and slowing progression in PD patients over the course of 6 months of treatment. Notably, studies have shown that NBP can alleviate motor deficits by inhibiting iron deposition, oxidative stress, and ferroptosis in the substantia nigra ( 16 ). Other studies showed that NBP treatment significantly ameliorated motor deficits in the substantia nigra of LPS-induced PD mice, reduced microglial activation, reduced nuclear α-synuclein deposition, and increased the survival rate of TH-positive cells ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson’s rats

Wang,

Li,

Wang

et al. 2024

Front. Neurol.

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BackgroundParkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease. Olfactory dysfunction (OD) is an important nonmotor feature of PD. Dl-3-n-Butylphthalide (NBP) is a synthetic compound isolated from Apium graveolens seeds. The present study was conducted to investigate the effect of NBP on olfaction in rotenone-induced Parkinson’s rats to explore the mechanism and pathway of OD in PD.MethodsThe PD model was established using rotenone-induced SD rats, divided into blank control, model, and treatment groups. A sham group was also established, with 10 rats in each group. The treatment group was given NBP (1 mg/kg, 10 mg/kg, and 100 mg/kg, dissolved in soybean oil) intragastrically for 28 days. Meanwhile, the control group rats were given intra-gastrically soybean oil. After behavioral testing, all rats were executed, and brain tissue was obtained. Proteomics and Proteomic quantification techniques (prm) quantification were used to detect proteomic changes in rat brain tissues.ResultsCompared with the control group, the model group showed significant differences in behavioral tests, and this difference was reduced after treatment. Proteomics results showed that after treatment with high-dose NBP, there were 42 differentially expressed proteins compared with the model group. Additionally, the olfactory marker (P08523) showed a significant upregulation difference. We then selected 22 target proteins for PRM quantification and quantified 17 of them. Among them, the olfactory marker protein was at least twofold upregulated in the RTH group compared to the model group.

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Section: Discussionmentioning

confidence: 99%

Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson’s rats

Wang,

Li,

Wang

et al. 2024

Front. Neurol.

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“…It exerts neuroprotective effects, and demonstrates the therapeutic potential for ischemic stroke ( Peng et al, 2023 ). Baicalin supresses oxidative stress by reducing ROS and protects GPX4 from membrane lipid peroxidation, thereby it curbs ferroptosis and plays a neuroprotective role in cerebrovascular diseases, neurodegenerative diseases, and other central nervous system diseases ( Yang et al, 2023 ).…”

Section: Biological Compounds Intervene In Ferroptosis In Lung Cancermentioning

confidence: 99%

Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds

Liang,

Wang,

et al. 2024

Front. Pharmacol.

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Lung cancer has high metastasis and drug resistance. The prognosis of lung cancer patients is poor and the patients’ survival chances are easily neglected. Ferroptosis is a programmed cell death proposed in 2012, which differs from apoptosis, necrosis and autophagy. Ferroptosis is a novel type of regulated cell death which is driven by iron-dependent lipid peroxidation and subsequent plasma membrane ruptures. It has broad prospects in the field of tumor disease treatment. At present, multiple studies have shown that biological compounds can induce ferroptosis in lung cancer cells, which exhibits significant anti-cancer effects, and they have the advantages in high safety, minimal side effects, and less possibility to drug resistance. In this review, we summarize the biological compounds used for the treatment of lung cancer by focusing on ferroptosis and its mechanism. In addition, we systematically review the current research status of combining nanotechnology with biological compounds for tumor treatment, shed new light for targeting ferroptosis pathways and applying biological compounds-based therapies.

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“…Recently, an increasing number of natural products have been isolated from natural resources as reagents for drug development for the treatment and prevention of diseases ( 74 ). These natural compounds are able to maintain effects such as iron homeostasis in the body, which are associated with inhibition of ferroptosis.…”

Section: Small-molecule Modulators Of Ferroptosismentioning

confidence: 99%

A deep insight into ferroptosis in lung disease: facts and perspectives

Zhang,

Xiang,

et al. 2024

Front. Oncol.

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In the last decade, ferroptosis has received much attention from the scientific research community. It differs from other modes of cell death at the morphological, biochemical, and genetic levels. Ferroptosis is mainly characterized by non-apoptotic iron-dependent cell death caused by iron-dependent lipid peroxide excess and is accompanied by abnormal iron metabolism and oxidative stress. In recent years, more and more studies have shown that ferroptosis is closely related to the occurrence and development of lung diseases. COPD, asthma, lung injury, lung fibrosis, lung cancer, lung infection and other respiratory diseases have become the third most common chronic diseases worldwide, bringing serious economic and psychological burden to people around the world. However, the exact mechanism by which ferroptosis is involved in the development and progression of lung diseases has not been fully revealed. In this manuscript, we describe the mechanism of ferroptosis, targeting of ferroptosis related signaling pathways and proteins, summarize the relationship between ferroptosis and respiratory diseases, and explore the intervention and targeted therapy of ferroptosis for respiratory diseases.

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Research progress in the molecular mechanism of ferroptosis in Parkinson's disease and regulation by natural plant products

Cited by 12 publications

References 295 publications

Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson’s rats

Effect of Dl-3-n-Butylphthalide on olfaction in rotenone-induced Parkinson’s rats

Ferroptosis: emerging roles in lung cancer and potential implications in biological compounds

A deep insight into ferroptosis in lung disease: facts and perspectives

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