Research progress of Bub3 gene in malignant tumors

Wang, Chenyang; Chen, Dating; Pan, Chenglong; Wang, Chunyan

doi:10.1002/cbin.11740

Cited by 6 publications

(5 citation statements)

References 82 publications

(120 reference statements)

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“…The spatial separation of kinase and phosphatase activities within the BUB complex is necessary to balance its functions as a checkpoint and in chromosome alignment [ 8 ]. Dysregulation of BUB1/3, the key mediators of spindle assembly checkpoints, has been reported to result in the incidence and development of various types of cancers, such as stomach cancer, leukemia, liver cancer, and breast cancer [ 9 , 10 ]. However, the role of BUB1/3 in lung adenocarcinoma remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of BUBs gene family in lung adenocarcinoma with immunological analysis

Wang

et al. 2023

Aging

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Lung adenocarcinoma (LUAD) is one of the most commonly malignant tumors, and major challenges remain in the treatment of LUAD. Budding uninhibited by benzimidazole 1/3 (BUB1/3) play significant roles in the process of spindle-assembly checkpoint (SAC) during mitosis. However, their roles in LUAD have not been established. Here, we performed an immunological analysis of BUB1/3 in LUAD using a comprehensive bioinformatics approach, quantitative real-time-PCR and Western blotting technique. Our results indicated that the expression levels of BUB1 and BUB3 in LUAD samples were higher than the expression levels in the control groups and were associated with some clinicopathologic parameters in patients with LUAD. BUB1/3 and their related genes were enriched in cell immune, and the immune infiltration analysis revealed that the BUB1/3 expression profile was significantly correlated with characteristics of immune cell infiltration. Survival analysis showed that the diseasefree survival and overall survival of patients with LUAD decreased with an increase in the BUB1/3 expression levels. The mRNA and protein expression levels of BUB1 and BUB3 in each of the LUAD cell lines were upregulated to varying degrees. BUB1 and BUB3 are the potential immunological therapeutic intervention targets for patients with LUAD.

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Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of BUBs gene family in lung adenocarcinoma with immunological analysis

Wang

et al. 2023

Aging

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“…Mutations or deletions of BUB1B and BUB3 proteins have been identified in colorectal cancer, osteosarcoma, and other tumors 47 – 49 . Abnormal expression of these SAC proteins is linked to tumor cell proliferation, apoptosis, and the cell cycle, significantly influencing tumor development, progression, metastasis, and prognosis.…”

Section: Discussionmentioning

confidence: 99%

A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in a pancreatic cancer cell line

Mondal,

Alyateem,

Mitchell

et al. 2024

Sci Rep

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Pancreatic adenocarcinoma is one of the most aggressive and lethal forms of cancer. Chemotherapy is the primary treatment for pancreatic cancer, but resistance to the drugs used remains a major challenge. A genome-wide CRISPR interference and knockout screen in the PANC-1 cell line with the drug nab-paclitaxel has identified a group of spindle assembly checkpoint (SAC) genes that enhance survival in nab-paclitaxel. Knockdown of these SAC genes (BUB1B, BUB3, and TTK) attenuates paclitaxel-induced cell death. Cells treated with the small molecule inhibitors BAY 1217389 or MPI 0479605, targeting the threonine tyrosine kinase (TTK), also enhance survival in paclitaxel. Overexpression of these SAC genes does not affect sensitivity to paclitaxel. These discoveries have helped to elucidate the mechanisms behind paclitaxel cytotoxicity. The outcomes of this investigation may pave the way for a deeper comprehension of the diverse responses of pancreatic cancer to therapies including paclitaxel. Additionally, they could facilitate the formulation of novel treatment approaches for pancreatic cancer.

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“…Six other SNP variants were suggestively associated with depression in the EM group, including the intronic regions of CHD2L, GMO5: rs2297754, intronic region of BUB3: rs75155690, intronic region of PDZRN4: rs79135118, 3'UTR region of ATOH8: rs1055770, the intergenic region between MIR197 and FAM241A: rs5897874, and the intergenic region between OR2F2 and OR2F1: rs41376753. BUB3 is located on chromosome 10q26.13 and encodes BUB3, a mitotic checkpoint protein belonging to the Bub protein family that plays an important role in the spindle assembly checkpoint (31). Abnormal BUB3 expression causes defective mitotic function, impaired spindle gate function, and chromosome instability, leading to aneuploidy and possibly tumorigenesis (31).…”

Section: Discussionmentioning

confidence: 99%

“…BUB3 is located on chromosome 10q26.13 and encodes BUB3, a mitotic checkpoint protein belonging to the Bub protein family that plays an important role in the spindle assembly checkpoint ( 31 ). Abnormal BUB3 expression causes defective mitotic function, impaired spindle gate function, and chromosome instability, leading to aneuploidy and possibly tumorigenesis ( 31 ). The GWAS catalog documented its association with exacerbations in children despite using long-acting beta 2-agonists and plasma metabolite kynurenic acid measurement ( 30 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of genetic risk loci for depression and migraine comorbidity in Han Chinese residing in Taiwan

Tsai

Tsai²,

Liang³

et al. 2023

Front. Psychiatry

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IntroductionThe genetic association between depression and migraine has not been well investigated in Asian populations. Furthermore, the genetic basis of depression and comorbid migraine subtypes remains nebulous. Hence, in the current study we investigate the susceptibility loci associated with depression and migraine comorbidity in the Han Chinese population in Taiwan.MethodsWe perform a genome-wide association study involving 966 migraine patients, with or without comorbid depression. Genotyping is performed using participant genomic DNA. Association analyses are performed for the entire migraine cohort (subgroups: episodic migraine, chronic migraine, and migraine with or without aura).ResultsResults show that the single nucleotide polymorphism variants of the CDH4 intron region (rs78063755), NTRK3-AS1 downstream region (rs57729223), and between LINC01918 and GPR45 (rs2679891) are suggestively associated with depression. Twenty additional susceptibility loci occur within the subgroups. A multivariate association study demonstrated that a variant in the intron region of CDH4 rs78063755 was associated with Beck Depression Inventory and Migraine Disability Assessment scores.DiscussionThe findings of this study identify several genetic loci suggestively associated with depression among migraine patients in the Han Chinese population. Moreover, a potential genetic basis has been characterized for depression and migraine comorbidity, thus providing genetic candidates for further investigation.

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Research progress of Bub3 gene in malignant tumors

Cited by 6 publications

References 82 publications

Comprehensive analysis of BUBs gene family in lung adenocarcinoma with immunological analysis

Comprehensive analysis of BUBs gene family in lung adenocarcinoma with immunological analysis

A whole-genome CRISPR screen identifies the spindle accessory checkpoint as a locus of nab-paclitaxel resistance in a pancreatic cancer cell line

Identification of genetic risk loci for depression and migraine comorbidity in Han Chinese residing in Taiwan

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