Research progress of neural stem cells as a source of dopaminergic neurons for cell therapy in Parkinson’s disease

Zhang, Lingling; Yang, Hao

doi:10.1007/s11033-024-09294-y

Mol Biol Rep

2024

DOI: 10.1007/s11033-024-09294-y

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Research progress of neural stem cells as a source of dopaminergic neurons for cell therapy in Parkinson’s disease

Lingling Zhang,

Hao Yang

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2024

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Cited by 2 publications

References 74 publications

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Research progress on the application of anti-gravity treadmill in the rehabilitation of Parkinson’s disease patients: a mini review

Zheng,

Shen,

Feng

et al. 2024

Front. Neurol.

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Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. It is the second most common chronic progressive neurodegenerative disease. PD still lacks a known cure or prophylactic medication. Current treatments primarily address symptoms without halting the progression of PD, and the side effects of dopaminergic therapy become more apparent over time. In contrast, physical therapy, with its lower risk of side effects and potential cardiovascular benefits, may provide greater benefits to patients. The Anti-Gravity Treadmill is an emerging rehabilitation therapy device with high safety, which minimizes patients’ fear and allows them to focus more on a normal, correct gait, and has a promising clinical application. Based on this premise, this study aims to summarize and analyze the relevant studies on the application of the anti-gravity treadmill in PD patients, providing a reference for PD rehabilitation practice and establishing a theoretical basis for future research in this area.

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Research progress on the application of anti-gravity treadmill in the rehabilitation of Parkinson’s disease patients: a mini review

Zheng,

Shen,

Feng

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

show abstract

Neural Stem Cell Therapy for Alzheimer’s Disease: A-State-of-the-Art Review

Shah,

Dar,

Jan

et al. 2024

JDAD

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Alzheimer’s disease (AD) is a brain disorder that is more prevalent in developed nations and remains one of most intractable conditions so far. It is characterized by a gradual onset, a prolonged progression, and an unclear pathophysiology. At the present time, there are no effective treatments available for the disease. However, human neural stem cells (hNSCs) have the capacity to substitute lost neurons in a functional manner, strengthen synaptic networks that have been compromised, and repair the damaged brain. Due to the unavailability of restorative therapeutics, there is a significant global burden on the economy. When it comes to the treatment of neurodegenerative diseases, NSCs provide a potentially game-changing approach to treating Alzheimer’s disease. Through the delivery of trophic factors that promote the viability and regeneration of lost neurons in experimental animals suffering from neurodegenerative disorders, these treatments have the potential to facilitate beneficial recuperation. Positive restorative outcomes may be achieved in a variety of ways, including the replacement of lost cells, the combining of cells, the secretion of neurotrophic factors, the formation of endogenous stem cells, and transdifferentiation. Conversely, there are obstacles that need to be overcome before NSC-based treatments can be used in clinical settings. This review article discusses current developments in the use of neural stem cells (NSCs) for the treatment of Alzheimer’s disease (AD). In addition, we highlight the difficulties and opportunities that are involved with the use of neural stem cell transplant treatment for Alzheimer’s disease.

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Research progress of neural stem cells as a source of dopaminergic neurons for cell therapy in Parkinson’s disease

Cited by 2 publications

References 74 publications

Research progress on the application of anti-gravity treadmill in the rehabilitation of Parkinson’s disease patients: a mini review

Research progress on the application of anti-gravity treadmill in the rehabilitation of Parkinson’s disease patients: a mini review

Neural Stem Cell Therapy for Alzheimer’s Disease: A-State-of-the-Art Review

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