Research Progress on Bioactive Factors against Skin Aging

He, Xin; Gao, Xinyu; Guo, Yifan; Xie, Weidong

doi:10.3390/ijms25073797

Cited by 5 publications

(2 citation statements)

References 99 publications

(111 reference statements)

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“…Some microbial, cellular, or protein products are claimed to be able to reprogram our immune system. In addition to these, lots of natural products including plant extracts or components have wide activities in terms of immune rehabilitation [120].…”

Section: Strategies or Related Products Aiming To Enhance Skin Immune...mentioning

confidence: 99%

“…Lots of cellular, microbial, protein-based, and natural products have shown significant anti-inflammatory activity. So, it should be not difficult for us to find some effective anti-aging products for skin [120,124]. The immune regulation strategies for skin aging and immune activation are summarized in Figure 2.…”

Section: Anti-immune Cell Over-activation/anti-inflammatory Strategie...mentioning

confidence: 99%

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Research Progress in Skin Aging and Immunity

He,

Gao,

Xie

2024

IJMS

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Skin aging is a complex process involving structural and functional changes and is characterized by a decrease in collagen content, reduced skin thickness, dryness, and the formation of wrinkles. This process is underpinned by multiple mechanisms including the free radical theory, inflammation theory, photoaging theory, and metabolic theory. The skin immune system, an indispensable part of the body’s defense mechanism, comprises macrophages, lymphocytes, dendritic cells, and mast cells. These cells play a pivotal role in maintaining skin homeostasis and responding to injury or infection. As age advances, along with various internal and external environmental stimuli, skin immune cells may undergo senescence or accelerated aging, characterized by reduced cell division capability, increased mortality, changes in gene expression patterns and signaling pathways, and altered immune cell functions. These changes collectively impact the overall function of the immune system. This review summarizes the relationship between skin aging and immunity and explores the characteristics of skin aging, the composition and function of the skin immune system, the aging of immune cells, and the effects of these cells on immune function and skin aging. Immune dysfunction plays a significant role in skin aging, suggesting that immunoregulation may become one of the important strategies for the prevention and treatment of skin aging.

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Section: Strategies or Related Products Aiming To Enhance Skin Immune...mentioning

confidence: 99%

Section: Anti-immune Cell Over-activation/anti-inflammatory Strategie...mentioning

confidence: 99%

Research Progress in Skin Aging and Immunity

He,

Gao,

Xie

2024

IJMS

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The Effects of an Oral Supplementation of a Natural Keratin Hydrolysate on Skin Aging: A Randomized, Double‐Blind, Placebo‐Controlled Clinical Study in Healthy Women

Tursi,

Nobile,

Cestone

et al. 2024

J of Cosmetic Dermatology

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BackgroundKeratin hydrolysates are active components used in food supplements to alleviate aging signs on skin, hair, and nails.AimsThis randomized, double‐blind, placebo‐controlled study evaluates a novel keratin hydrolysate obtained from poultry feathers. This feather keratin hydrolysate (FKH) results in a characteristic mix of free L‐amino acids (≥ 83.5%). FKH was administered as a food supplement to a panel of adult women showing aging physiological signs.MethodsParticipants were randomly assigned in three groups to receive daily dosages of 500 or 1000 mg of FKH or placebo for 90 days. Parameters of skin roughness, wrinkle features, deep skin moisturization, skin maximum elongation and elasticity, skin thickness, skin anisotropy, skin density, gloss of skin, hair and nails, and nail hardness were evaluated. Subjects also answered a questionnaire related to the treatment efficacy perception.ResultsBoth FKH treatments showed a significant improvement of all parameters compared to day 0 and to placebo, with an exception for fiber anisotropy and fiber density which showed a significant improvement compared to day 0 and a tendency to improve compared to placebo. These measurements were bolstered by the results of a self‐assessment questionnaire, showing an overall set of positive answers for both treatments compared to placebo.ConclusionsOral supplementation of FKH for 90 days is associated with an improvement in the appearance of facial skin, hair, and nails. This study highlights the benefits of free L‐amino acids mix as potential aminobiotics and not just as building blocks of proteins, suggesting a new perspective of nutricosmetic food.

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Anti-Aging Effects of Low-Molecular-Weight Collagen Peptide Supplementation on Facial Wrinkles and Skin Hydration: Outcomes from a Six-Week Randomized, Double-Blind, Placebo-Controlled Trial

Carrillo-Norte,

García-Mir,

Quintana

et al. 2024

Cosmetics

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In recent decades, there has been a rising demand for anti-aging interventions aimed at postponing or potentially reversing indicators of skin aging. The use of collagen-based nutraceutical supplements has gained popularity as they have shown promise in enhancing skin health and reducing signs of aging. The aim of this randomized, placebo-controlled, blinded study was to investigate the effects of 2.5 g COLLinstant® LMW, a novel cosmeceutical containing low-molecular-weight (≤1000 Da) collagen peptides, on skin aging and health. The trial was conducted with 80 healthy women aged 30 years and older. They received a daily oral dose of either the food supplement (n = 40) or placebo (n = 40) for six weeks. Skin assessment was performed based on validated objective methods, such as Visioface 1000D (skin wrinkling), cutometry (elasticity and fatigue), and corneometry (skin hydration) at baseline (T0) and at week 6 (T6). After 6 weeks, participants that received collagen had significant improvements in biometric skin wrinkle parameters from baseline, with a reduction in volume by 46%, in area by 44%, and in depth by 9%, along with a greater increase in skin moisturization (by 34%) than those in the placebo group (p < 0.001). The food supplement did not significantly modify skin firmness or fatigue and had only slight beneficial effects on skin elasticity. The investigational product was well tolerated. The observed effects aligned closely with the subjective assessments reported by study participants. The study provides substantiated evidence supporting the efficacy of low-molecular-weight collagen peptides in restoring altered skin biometric parameters, as objectively assessed. Thus, regular supplementation with this nutraceutical may contribute to achieving smoother and more radiant skin.

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Research Progress on Bioactive Factors against Skin Aging

Cited by 5 publications

References 99 publications

Research Progress in Skin Aging and Immunity

Research Progress in Skin Aging and Immunity

The Effects of an Oral Supplementation of a Natural Keratin Hydrolysate on Skin Aging: A Randomized, Double‐Blind, Placebo‐Controlled Clinical Study in Healthy Women

Anti-Aging Effects of Low-Molecular-Weight Collagen Peptide Supplementation on Facial Wrinkles and Skin Hydration: Outcomes from a Six-Week Randomized, Double-Blind, Placebo-Controlled Trial

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