Research Progress on Fumonisin B1 Contamination and Toxicity: A Review

Chen, Jia; Wen, Jun; Tang, Y D; Shi, Jichao; Mu, Guodong; Yan, Rong; Cai, Jing; Long, Miao

doi:10.3390/molecules26175238

Cited by 82 publications

(49 citation statements)

References 154 publications

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“…4 Intraday repeatability measured on 12 samples spiked before extraction with 6250 pmol/g liver or 1563 pmol/mL plasma. 5 Interday repeatability measured on 4 consecutive days in 3 samples per day spiked before extraction with 6250 pmol/g liver or 1563 pmol/mL plasma. a = slope of the calibration curve; R 2 = coefficient of determination; SSE = signal suppression and enhancement; RA = apparent recovery; R = recovery; RSD = relative standard deviation.…”

Section: Validation Of the Methods On Ismentioning

confidence: 99%

See 1 more Smart Citation

Strong Alterations in the Sphingolipid Profile of Chickens Fed a Dose of Fumonisins Considered Safe

Tardieu

Matard-Mann²,

Collén³

et al. 2021

Toxins

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Fumonisins (FB) are mycotoxins known to exert most of their toxicity by blocking ceramide synthase, resulting in disruption of sphingolipid metabolism. Although the effects of FB on sphinganine (Sa) and sphingosine (So) are well documented in poultry, little information is available on their other effects on sphingolipids. The objective of this study was to analyze the effects of FB on the hepatic and plasma sphingolipidome in chickens. The first concern of this analysis was to clarify the effects of FB on hepatic sphingolipid levels, whose variations can lead to numerous toxic manifestations. The second was to specify the possible use of an alteration of the sphingolipidome as a biomarker of exposure to FB, in addition to the measurement of the Sa:So ratio already widely used. For this purpose, we developed an UHPLC MS/MS method that enabled the determination of 82 SL, including 10 internal standards, in chicken liver and plasma. The validated method was used to measure the effects of FB administered to chickens at a dose close to 20 mg FB1 + FB2/kg feed for 9 days. Significant alterations of sphingoid bases, ceramides, dihydroceramides, glycosylceramides, sphingomyelins and dihydrosphingomyelins were observed in the liver. In addition, significant increases in plasma sphinganine 1-phosphate, sphingosine 1-phosphate and sphingomyelins were observed in plasma. Interestingly, partial least-squares discriminant analysis of 11 SL in plasma made it possible to discriminate exposed chickens from control chickens, whereas analysis of Sa and So alone revealed no difference. In conclusion, our results show that the effects of FB in chickens are complex, and that SL profiling enables the detection of exposure to FB when Sa and So fail.

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Section: Validation Of the Methods On Ismentioning

confidence: 99%

“…Fumonisins are mycotoxins produced by fungi of the genus Fusarium that are found worldwide [1][2][3][4][5]. Among the different groups of fumonisins identified, fumonisin B (FB), and in particular fumonisin B1 (FB1) and fumonisin B2 (FB2), are the most widespread and the most frequently studied [6].…”

Section: Introductionmentioning

confidence: 99%

Strong Alterations in the Sphingolipid Profile of Chickens Fed a Dose of Fumonisins Considered Safe

Tardieu

Matard-Mann²,

Collén³

et al. 2021

Toxins

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show abstract

“…Recently, the toxicity of FB1 has aroused widespread public concern [13]. Several studies have shown that FB1 can pose many toxic effects (neurotoxic, hepatotoxic and nephrotoxic) in humans [9,14,15]. The International Agency for Research on Cancer (IARC) classified FB1 as group 2B (possible carcinogenic to humans), since there is no direct established causal association between FB1 exposure and cancer in humans (IARC, 2002).…”

Section: Introductionmentioning

confidence: 99%

Bioenergetic Status of the Intestinal and Hepatic Cells after Short Term Exposure to Fumonisin B1 and Aflatoxin B1

Chen

Abdallah

Grootaert

et al. 2022

IJMS

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Fumonisin B1 (FB1) and aflatoxin B1 (AFB1) are frequent contaminants of staple foods such as maize. Oral exposure to these toxins poses health hazards by disrupting cellular signaling. However, little is known regarding the multifaced mitochondrial dysfunction-linked toxicity of FB1 and AFB1. Here, we show that after exposure to FB1 and AFB1, mitochondrial respiration significantly decreased by measuring the oxygen consumption rate (OCR), mitochondrial membrane potential (MMP) and reactive oxygen species (ROS). The current work shows that the integrity of mitochondria (MMP and ROS), that is the central component of cell apoptosis, is disrupted by FB1 and AFB1 in undifferentiated Caco-2 and HepG2 cells as in vitro models for human intestine and liver, respectively. It hypothesizes that FB1 and AFB1 could disrupt the mitochondrial electron transport chain (ETC) to induce mitochondrial dysfunction and break the balance of transferring H+ between the mitochondrial inner membrane and mitochondrial matrix, however, the proton leak is not increasing and, as a result, ATP synthesis is blocked. At the sub-toxic exposure of 1.0 µg/mL for 24h, i.e., a viability of 95% in Caco-2 and HepG2 cells, the mitochondrial respiration was, however, stimulated. This suggests that the treated cells could reserve energy for mitochondrial respiration with the exposure of FB1 and AFB1, which could be a survival advantage.

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“…They primarily contaminate corn (maize), corn-derived products, asparagus, sorghum, beer, rice, soybeans, and animal feed, as well as the food chain, threatening to food safety and minimizing animal production ( 1 – 4 ). According to recent estimates, 60–80% of mycotoxin contamination occurs naturally in food and feed, posing a risk to human and animal health worldwide ( 5 ). Mycotoxins can enter the human body directly through the consumption of plant-based foods with primary contamination or indirectly through the transfer of toxins and their metabolites into animal-derived products (milk, meat and eggs) with secondary contamination.…”

Section: Introductionmentioning

confidence: 99%

Protocatechuic acid: A novel detoxication agent of fumonisin B1 for poultry industry

Wang

Chen

et al. 2022

Front. Vet. Sci.

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Fumonisin B1 (FB1) is a major fusarium mycotoxin that largely contaminates feedstuffs and foods, posing a health risk to both animals and humans. This mycotoxin can enter the human body directly through contaminated food consumption or indirectly by toxins and their metabolites. In a prior study, feed-borne FB1 is one of the leading mycotoxins in breeder eggs, leading to reduced hatchability and gizzard ulceration in chicken progenies. Currently, no effective way is available to remove FB1 from feeds and human-contaminated foods. We hypothesize that FB1 can be reduced to low risk by protocatechuic acid (PCA). To assess the ability of FB1 to be degraded in vivo, 1 ppm of FB1 was treated with PCA, or D-glucose, or silymarin, or anti-FB1 monoclonal antibody. Our study revealed that both D-glucose and PCA exhibited 53.4 and 71.43% degradation, respectively, at 80°C for 2 h, while 35.15% of FB1 detoxification was determined in the silymarin group at 60°C for 0.5 h. A dose-dependent manner was found after treatment with D-glucose or PCA at 80°C for 2 h. As for detoxification of anti-FB1 monoclonal antibody, the 1:3,000 dilution induced significant FB1 detoxification, accounting for 25.9% degradation at 25°C for 2 h. Furthermore, 50 SPF 11-day-old embryonated eggs were divided into 10 groups, with five eggs per group. Post treatment with PCA or D-glucose, or silymarin or anti-FB1 monoclonal antibody, the treated samples were inoculated into albumens and monitored daily until the hatching day. Consequently, 100% of the chickens survived in the D-glucose group and other control groups, except for the FB1 control group, while 80, 80, and 60% hatching rates were found in the PCA-treated group, the anti-FB1 monoclonal antibody-treated group, and the silymarin-treated group. Additionally, both the FB1 group and the silymarin-treated group yielded lower embryo growth than other groups did. Postmortem, lower gizzard ulceration index was determined in the PCA-treated group and the anti-FB1 monoclonal antibody-treated group compared to those of the silymarin-treated group and D-glucose-treated group. Based on the above evidence, PCA is a promising detoxification to reduce FB1 contamination in the poultry industry, contributing to the eradication of mycotoxin residuals in the food chain and maintaining food security for human beings.

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Research Progress on Fumonisin B1 Contamination and Toxicity: A Review

Cited by 82 publications

References 154 publications

Strong Alterations in the Sphingolipid Profile of Chickens Fed a Dose of Fumonisins Considered Safe

Strong Alterations in the Sphingolipid Profile of Chickens Fed a Dose of Fumonisins Considered Safe

Bioenergetic Status of the Intestinal and Hepatic Cells after Short Term Exposure to Fumonisin B1 and Aflatoxin B1

Protocatechuic acid: A novel detoxication agent of fumonisin B1 for poultry industry

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