Research progress on hepatic machine perfusion

Abstract

Nowadays, liver transplantation is the most effective treatment for end-stage liver disease. However, the increasing imbalance between growing demand for liver transplantation and the shortage of donor pool restricts the development of liver transplantation. How to expand the donor pool is a significant problem to be solved clinically. Many doctors have devoted themselves to marginal grafting, which introduces livers with barely passable quality but a high risk of transplant failure into the donor pool. However, existing common methods of preserving marginal grafts lead to both high risk of postoperative complications and high mortality. The application of machine perfusion allows surgeons to make marginal livers meet the standard criteria for transplant, which shows promising prospect in preserving and repairing donor livers and improving ischemia reperfusion injury. This review summarizes the progress of recent researches on hepatic machine perfusion.

Multiple Shades of Gray—Macrophages in Acute Allograft Rejection

“…Hence, similarly to the polarization of infiltrating macrophages, there also seems to exist a fragile equilibrium between TRM. The exponential development and use of ex vivo normothermic perfusion techniques could represent the ideal platform to further pursue TRM as treatment target [114,115].…”