Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs

Hao, Ya; Xing, Mingjie; Gu, Xianhong

doi:10.3390/ani11051384

Cited by 69 publications

(70 citation statements)

References 165 publications

(163 reference statements)

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“…The antioxidant mechanisms of EOs are associated with their capability to donate hydrogen or an electron to free radicals (ROS) as well as with their ability to detach unpaired electrons inside the aromatic structure to counter free radicals and protect biological molecules from oxidation [ 69 , 70 ]. The supplementation of pig diets with EOs contributed significantly to controlling body damages produced by the disruption in redox balance due to excess ROS species in the organism of pigs [ 69 , 71 ]. Thus, EOs such as propolis EOs, could be used to modulate the oxidative stress in pigs, and prevent DNA, membrane, protein, and lipid damage in their organism [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

“…The supplementation of pig diets with EOs contributed significantly to controlling body damages produced by the disruption in redox balance due to excess ROS species in the organism of pigs [ 69 , 71 ]. Thus, EOs such as propolis EOs, could be used to modulate the oxidative stress in pigs, and prevent DNA, membrane, protein, and lipid damage in their organism [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

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Essential Oils Extracted from Organic Propolis Residues: An Exploratory Analysis of Their Antibacterial and Antioxidant Properties and Volatile Profile

et al. 2021

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The industrial processing of crude propolis generates residues. Essential oils (EOs) from propolis residues could be a potential source of natural bioactive compounds to replace antibiotics and synthetic antioxidants in pig production. In this study, we determined the antibacterial/antioxidant activity of EOs from crude organic propolis (EOP) and from propolis residues, moist residue (EOMR), and dried residue (EODR), and further elucidated their chemical composition. The EOs were extracted by hydrodistillation, and their volatile profile was tentatively identified by GC-MS. All EOs had an antibacterial effect on Escherichia coli and Lactobacillus plantarum as they caused disturbances on the growth kinetics of both bacteria. However, EODR had more selective antibacterial activity, as it caused a higher reduction in the maximal culture density (D) of E. coli (86.7%) than L. plantarum (46.9%). EODR exhibited mild antioxidant activity, whereas EOMR showed the highest antioxidant activity (ABTS = 0.90 μmol TE/mg, FRAP = 463.97 μmol Fe2+/mg) and phenolic content (58.41 mg GAE/g). Each EO had a different chemical composition, but α-pinene and β-pinene were the major compounds detected in the samples. Interestingly, specific minor compounds were detected in a higher relative amount in EOMR and EODR as compared to EOP. Therefore, these minor compounds are most likely responsible for the biological properties of EODR and EOMR. Collectively, our findings suggest that the EOs from propolis residues could be resourcefully used as natural antibacterial/antioxidant additives in pig production.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Essential Oils Extracted from Organic Propolis Residues: An Exploratory Analysis of Their Antibacterial and Antioxidant Properties and Volatile Profile

et al. 2021

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“…Chronic inflammation in adipose tissue due to excessive fat accumulation would promote proinflammatory status and oxidative stress [ 4 ]. The substantial rise in the generation of free radicals in humans and animals that disrupts the antioxidation-oxidation equilibrium is referred to as oxidative stress [ 5 ]. A variety of illnesses have been reported to be pathologically caused by oxidative stress, which has been shown to be correlated with fat accumulation [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…In pigs, a significant number of free radicals are produced because of oxidative damage, which leads to several diseases [ 6 ]. More importantly, the development of the pig industry would be hampered by oxidative stress due to oxidative stress directly limiting the growth performance and health of pigs [ 5 ]. Therefore, studying the oxidative stress in pigs is of great significance to pig production, as well as other animals and human health.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Possible Link between the Gut Microbiome and Fat Deposition in Pigs

Zhao

Xiang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Excessive lipid accumulation and high oxidative stress have become a serious health and economic problem in the pig industry. Fatness characteristics are crucial in pig production since they are closely related to meat quality. The gut microbiome is well acknowledged as a key element in fat deposition. But the link between gut microbiota and fat accumulation in pigs remains elusive. To examine whether there is a link between pigs’ gut microbiome, lipogenic properties, and oxidative stress, we selected 5 high-fat pigs and 5 low-fat pigs from 60 250-day-old Jinhua pigs in the present study and collected the colon content, serum sample, and liver and abdominal fat segments from each pig for metagenomic analysis, the oxidative stress assay, and RT-qPCR analysis, respectively. The backfat thickness and fat content of the longissimus dorsi muscle were considerably higher in the high-fat pigs than in the low-fat pigs ( P < 0.05 ). An obvious difference in GSH-Px and MDA in the serum between the high- and low-fat pigs was observed. After RT-qPCR analysis, we found the gene expression of ACC1 and SREBP1 in the liver and FAS, PPARγ, and LPL in the abdominal fat were significantly higher in high-fat pigs than in low-fat pigs ( P < 0.05 ). Additionally, metagenomic sequencing revealed that high-fat pigs had a higher abundance of Archaeal species with methanogenesis functions, leading to more-efficient fat deposition, while low-fat pigs had higher abundances of butyrate-producing bacteria species that improved the formation of SCFAs, especially butyrate, thus alleviating fat deposition in pigs. Furthermore, a total of 17 CAZyme families were identified to give significant enrichments in different fat phenotypes of pigs. This study would provide a detailed understanding of how the gut microbiome influences fat deposition in pigs, as well as a hint for improving growth performance and fatness traits by manipulating the gut microbiome.

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“…Oxidative stress also communicates with signaling molecules to exert a physiopathogenic response. Overall, it has a pronounced effect on gut health in pigs and beef calves which ultimately minimizes its production [ 12 , 13 ]. Research on gut microbiota in pigs would not only help construct a healthy gut of the animal but also benefit human studies due to the similarity of anatomic and physiologic attributes.…”

Section: Introductionmentioning

confidence: 99%

The Role of Polyphenols in Regulation of Heat Shock Proteins and Gut Microbiota in Weaning Stress

Hussain

Wang

Murtaza

et al. 2021

Oxidative Medicine and Cellular Longevity

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Gut microbiota is the natural residents of the intestinal ecosystem which display multiple functions that provide beneficial effects on host physiology. Disturbances in gut microbiota in weaning stress are regulated by the immune system and oxidative stress-related protein pathways. Weaning stress also alters gut microbiota response, limits digestibility, and influences animal productive performance through the production of inflammatory molecules. Heat shock proteins are the molecular chaperones that perform array functions from physiological to pathological point of view and remodeling cellular stress response. As it is involved in the defense mechanism, polyphenols ensure cellular tolerance against enormous stimuli. Polyphenols are nature-blessed compounds that show their existence in plenty of amounts. Due to their wider availability and popularity, they can exert strong immunomodulatory, antioxidative, and anti-inflammatory activities. Their promising health-promoting effects have been demonstrated in different cellular and animal studies. Dietary interventions with polyphenols may alter the gut microbiome response and attenuate the weaning stress related to inflammation. Further, polyphenols elicit health-favored effects through ameliorating inflammatory processes to improve digestibility and thereby exert a protective effect on animal production. Here, in this article, we will expand the role of dietary polyphenol intervention strategies in weaning stress which perturbs gut microbiota function and also paid emphasis to heat shock proteins in gut health. This review article gives new direction to the feed industry to formulate diet containing polyphenols which would have a significant impact on animal health.

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Research Progress on Oxidative Stress and Its Nutritional Regulation Strategies in Pigs

Cited by 69 publications

References 165 publications

Essential Oils Extracted from Organic Propolis Residues: An Exploratory Analysis of Their Antibacterial and Antioxidant Properties and Volatile Profile

Essential Oils Extracted from Organic Propolis Residues: An Exploratory Analysis of Their Antibacterial and Antioxidant Properties and Volatile Profile

Exploring the Possible Link between the Gut Microbiome and Fat Deposition in Pigs

The Role of Polyphenols in Regulation of Heat Shock Proteins and Gut Microbiota in Weaning Stress

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