Research progress on piperidine-containing compounds as agrochemicals

Sun, Wei; Liao, Anjing; Lei, Li; Tang, Xu; Wang, Ya; Wu, Jian

doi:10.1016/j.cclet.2024.109855

Chinese Chemical Letters

2025

DOI: 10.1016/j.cclet.2024.109855

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Research progress on piperidine-containing compounds as agrochemicals

Wei Sun,

Anjing Liao,

Li Lei

et al.

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Cited by 4 publications

References 88 publications

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Synthesis and Biological Evaluation of Benzamide Compounds as Insecticides Agents Against Spodoptera Frugiperda (Lepidoptera: Noctuidae)

Abd El‐Lateef,

Khalaf,

Gouda

et al. 2024

Chemistry & Biodiversity

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Due to its severe damage, Spodoptera frugiperda is receiving attention as one of the biggest dangers to world food security. Although there are numerous insecticides that are widely and successfully used to control S. frugiperda, they do not have an immediate effect. In our work focusing for synthesized twelve novel benzamide derivatives and examined their insecticidal effectiveness against S. frugiperda larvae in their second & fourth larvae instars, with the aim of further improving the insecticidal activity based on combination principles. Several spectroscopic methods, including elemental analysis, NMR & infrared spectroscopy, were employed for confirming the structure of the newly designed products. It has been discovered that most compounds show good of promising efficacy. With an LC50 of 24.8 mg/L for larvae in the second instar & 56.2 mg/L for larvae in the fourth instar, compound 23 was the most active. Among all compounds 11, 22 and 20 exhibited excellent results. Furthermore, a number of biological and histopathological properties of the demonstration compounds of the produced goods under laboratory conditions were also examined. This work further demonstrates the anti‐proliferation of S. frugiperda and offers fresh ideas for the manufacture of benzamide derivatives.

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Synthesis and Biological Evaluation of Benzamide Compounds as Insecticides Agents Against Spodoptera Frugiperda (Lepidoptera: Noctuidae)

Abd El‐Lateef,

Khalaf,

Gouda

et al. 2024

Chemistry & Biodiversity

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Synthesis of Indol-3-yl Morpholino Derivatives Containing a Hydrazone Moiety as Potential Antiplant Virus Agents

Sun,

Huang,

Yang

et al. 2024

J. Agric. Food Chem.

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A series of indol-3-yl morpholino derivatives containing a hydrazone moiety were designed and synthesized using indole-3-carboxylic acid as the starting material. The antiviral activities of the synthesized compounds were systematically evaluated. Compound D35, optimized using the comparative molecular field analysis (CoMFA) model, exhibited the most potent inhibitory activity against Tobacco mosaic virus (TMV) in vivo with a 50% effective concentration (EC 50 ) value of 69.9 mg/L and exceeded that of Ningnanmycin (142.4 mg/L). Molecular docking and molecular dynamics simulations revealed that compound D35 could form stable interactions with the TMV coat protein (CP), exhibiting a lower binding energy of −9.37 kcal/mol compared to that of Ningnanmycin (−8.55 kcal/mol). Microscale thermophoresis (MST) experiments further confirmed the stronger binding affinity of compound D35 for the TMV CP than Ningnanmycin. Additionally, transmission electron microscopy (TEM) demonstrated that compound D35 effectively disrupts the TMV particles and inhibits their spread. These collective findings strongly suggest that compound D35 has the potential to serve as a lead compound for the development of novel antiviral agents.

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Recent Advances of Coumarin-Type Compounds in Discovery of Pesticides

Tang,

Wang,

Guo

et al. 2024

J. Agric. Food Chem.

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Coumarin, a naturally occurring active ingredient with various biological activities in pesticides, is commonly found in plants belonging to the Rutaceae and Apiaceae families. Thanks to its unique structural properties and natural benefits, coumarin and its derivatives exhibit a wide range of physiological activities, including insecticidal, antifungal, antibacterial, herbicidal, and antiviral properties. These compounds have attracted considerable interest in the field of pesticide development, although there is a lack of comprehensive reviews on their use in pesticides. This Review aims to provide a detailed overview of the applications of coumarin and its derivatives in pesticides, covering biological activities, structure−activity relationship analyses, and mechanisms of action. It is hoped that this Review will offer new insights into the discovery and mechanisms of these compounds in pesticide development.

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Research progress on piperidine-containing compounds as agrochemicals

Cited by 4 publications

References 88 publications

Synthesis and Biological Evaluation of Benzamide Compounds as Insecticides Agents Against Spodoptera Frugiperda (Lepidoptera: Noctuidae)

Synthesis and Biological Evaluation of Benzamide Compounds as Insecticides Agents Against Spodoptera Frugiperda (Lepidoptera: Noctuidae)

Synthesis of Indol-3-yl Morpholino Derivatives Containing a Hydrazone Moiety as Potential Antiplant Virus Agents

Recent Advances of Coumarin-Type Compounds in Discovery of Pesticides

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