Research progress on quality markers of traditional Chinese medicine

Zhang, Hongbing; Yu, Zhishui; Liu, Changxiao

doi:10.1016/j.jpba.2022.114588

Cited by 44 publications

(27 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2 The species was selected as "Homo sapiens, " and all the component targets obtained from the two databases were combined and duplicates were removed to obtain the component targets. The keywords "hyperuricaemia, gouty arthritis" were used in OMIM, 3 Drugbank, 4 GeneCards, 5 and DisGeNET. 6 The component targets and disease targets were imported into the Venny 2.1 online mapping tool platform for analysis, and the intersection targets were obtained as component-disease key targets.…”

Section: Network Pharmacology and Molecular Dockingmentioning

confidence: 99%

“…Academician Changxiao Liu. has proposed the concept of "Quality markers" (Q markers) since 2016 (4,5), and many researchers have subsequently used it as an entry point for research (6). It is well-known that some components of TCM are more active and are the main medicinal components, for example, artemisinin in Artemisia annua L., berberine in Coptis chinensis Franch., baicalin in Scutellaria baicalensis Georgi, and so on (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Bioactive-Chemical Quality Markers Revealed: An Integrated Strategy for Quality Control of Chicory

Lin

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

As a miraculous Xinjiang Uyghur customary traditional Chinese medicine (TCM), Chicory (Cichorium glandulosum Boiss.et Huet and Cichorium intybus L.) has been found to have therapeutic potential for metabolic diseases in recent years. Although it is widely used as an ethnic medicine, there is still a lack of targeted quality control indicators in quality standards. Hence, this study was conducted to further develop a strategy to reveal bioactive-chemical quality markers based on the existing foundation. First, through the comparative screening of fingerprint profiles of a large amount of Cichorium glandulosum Boiss.et Huet and Cichorium intybus L., superiority components were found to be potential indicators of chemical quantitative properties for the roots and above-ground parts. The results of content determination showed that their contents differed among different species and parts. Second, the potential dominant components were further confirmed using network pharmacology and molecular docking techniques. Again, the results of RAW264.7 cells and L02 cells experiments showed that chicory acid and lactucin were the main components that could reflect the anti-inflammatory and uric acid-lowering potential of chicory. Finally, under this strategy, this study reveals that cichoric acid and lactucin have the properties of quality markers and quality control of chicory. In a word, this work contributes to the quality control, standard improvement, and rational clinical use of chicory.

show abstract

Section: Network Pharmacology and Molecular Dockingmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bioactive-Chemical Quality Markers Revealed: An Integrated Strategy for Quality Control of Chicory

Lin

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…Therefore, active, unique, toxic, and unstable ingredients are usually selected from HMPs as Q-markers. Active ingredients are used as Q-markers to study the effects of the ecological environment, construction method, and harvesting method of TCMs; toxic ingredients are used as Q-markers to study TCM contraindications; unstable ingredients are used as Q-markers to study the main biosynthetic pathways of TCM components 30 , 31 , 32 .…”

Section: Q-marker Principlesmentioning

confidence: 99%

Supermolecules as a quality markers of herbal medicinal products

Cheng

Han

et al. 2022

Heliyon

View full text Add to dashboard Cite

“…2 The elucidation of the chemical composition of TCM herbal formulae is required as a basis for research into a prescription's efficacy and safety. 3 Ultrahigh-performance liquid chromatography combined with high-resolution mass spectrometry (UHPLC−HRMS) has proven to be an excellent chemical analysis method for complex systems due to its high sensitivity and specificity. 4,5 UHPLC−HRMS has been widely used in the detection of small molecules from plants, 6 animals, 7 and human samples.…”

Section: Introductionmentioning

confidence: 99%

“…The chemical components of TCM prescriptions are complex mixtures, especially those composed of several herbs . The elucidation of the chemical composition of TCM herbal formulae is required as a basis for research into a prescription’s efficacy and safety …”

Section: Introductionmentioning

confidence: 99%

UHPLC Q-Orbitrap Mass Spectrometry-Based Molecular Networking for Identification of Chemical Constituents in the Multi-Herb Formula Runyan Mixture

Zhang

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Traditional Chinese medicine (TCM) in-hospital preparations are approved for use only in the hospital where they are prepared. They are widely used in China because of their efficacy and affordable price. However, few researchers focused on their quality controls and treatment mechanisms, for which a key consideration is the elucidation of their chemical composition. Runyan mixture (RY) is a typical in-hospital TCM preparation comprising a formula of eight herbal drugs used for adjuvant therapy of upper respiratory tract infections. The chemical constituents of formulated RY have not yet been elucidated. In the present work, RY was analyzed by a ultrahigh-performance liquid chromatography system equipped with high-resolution orbitrap mass spectrometry (MS). The acquired MS data were processed by MZmine and a feature-based molecular networking was constructed to identify the metabolites of RY. 165 compounds including 41 flavonoid O-glycosides, 11 flavonoid C-glycosides, 18 quinic acids, 54 coumaric acids, 11 iridoids, and 30 others were identified. This study demonstrates an efficient method to identify compounds in complex herbal drug mixtures using high-resolution MS and molecular networking tools which will support future research into quality controls and treatment mechanisms of in-hospital TCM preparations.

show abstract

Research progress on quality markers of traditional Chinese medicine

Cited by 44 publications

References 37 publications

Bioactive-Chemical Quality Markers Revealed: An Integrated Strategy for Quality Control of Chicory

Bioactive-Chemical Quality Markers Revealed: An Integrated Strategy for Quality Control of Chicory

Supermolecules as a quality markers of herbal medicinal products

UHPLC Q-Orbitrap Mass Spectrometry-Based Molecular Networking for Identification of Chemical Constituents in the Multi-Herb Formula Runyan Mixture

Contact Info

Product

Resources

About