Research progress on the activation mechanism of NLRP3 inflammasome in septic cardiomyopathy

Wen, Yuqi; Liu, Yang; Liu, Weihong; Liu, Wenli; Dong, Jinyan; Liu, Qingkuo; Hao, Hao; Ren, Hongsheng

doi:10.1002/iid3.1039

Cited by 3 publications

(2 citation statements)

References 93 publications

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“…The results demonstrate a correlation between oxidative and nitrosative stress imbalance and the pathophysiology of cardiac dysfunction in sepsis [ 78 , 79 , 80 ]. This could suggest a greater involvement of oxidative stress in the pathogenesis of septic development [ 81 , 82 , 83 ].…”

Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Sepsis: A Focus on Cardiac Pathology

Bertozzi,

Ferrara,

Di Fazio

et al. 2024

IJMS

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This study aims to analyze post-mortem human cardiac specimens, to verify and evaluate the existence or extent of oxidative stress in subjects whose cause of death has been traced to sepsis, through immunohistological oxidative/nitrosative stress markers. Indeed, in the present study, i-NOS, NOX2, and nitrotyrosine markers were higher expressed in the septic death group when compared to the control group, associated with also a significant increase in 8-OHdG, highlighting the pivotal role of oxidative stress in septic etiopathogenesis. In particular, 70% of cardiomyocyte nuclei from septic death specimens showed positivity for 8-OHdG. Furthermore, intense and massive NOX2-positive myocyte immunoreaction was noticed in the septic group, as nitrotyrosine immunostaining intense reaction was found in the cardiac cells. These results demonstrated a correlation between oxidative and nitrosative stress imbalance and the pathophysiology of cardiac dysfunction documented in cases of sepsis. Therefore, subsequent studies will focus on the expression of oxidative stress markers in other organs and tissues, as well as on the involvement of the intracellular pattern of apoptosis, to better clarify the complex pathogenesis of multi-organ failure, leading to support the rationale for including therapies targeting redox abnormalities in the management of septic patients.

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Section: Discussionmentioning

confidence: 99%

Oxidative Stress in Sepsis: A Focus on Cardiac Pathology

Bertozzi,

Ferrara,

Di Fazio

et al. 2024

IJMS

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show abstract

“…Moreover, AQP3 seemed to improve the outcome in a sepsis mouse model [8]. In addition, AQP3 seems to be involved in the formation of the inflammasome [23], which is important in sepsis pathophysiology [24][25][26]. However, it is unclear whether AQP3 has an impact on the outcome of sepsis patients.…”

Section: Introductionmentioning

confidence: 99%

The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion

Ziehe,

Marko,

Thon

et al. 2024

IJMS

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Sepsis is a common life-threatening disease caused by dysregulated immune response and metabolic acidosis which lead to organ failure. An abnormal expression of aquaporins plays an important role in organ failure. Additionally, genetic variants in aquaporins impact on the outcome in sepsis. Thus, we investigated the polymorphism (rs17553719) and expression of aquaporin-3 (AQP3) and correlated these measurements with the survival of sepsis patients. Accordingly, we collected blood samples on several days (plus clinical data) from 265 sepsis patients who stayed in different ICUs in Germany. Serum plasma, DNA, and RNA were then separated to detect the promotor genotypes of AQP3 mRNA expression of AQP3 and several cytokines. The results showed that the homozygote CC genotype exhibited a significant decrease in 30-day survival (38.9%) compared to the CT (66.15%) and TT genotypes (76.3%) (p = 0.003). Moreover, AQP3 mRNA expression was significantly higher and nearly doubled in the CC compared to the CT (p = 0.0044) and TT genotypes (p = 0.018) on the day of study inclusion. This was accompanied by an increased IL-33 concentration in the CC genotype (day 0: p = 0.0026 and day 3: p = 0.008). In summary, the C allele of the AQP3 polymorphism (rs17553719) shows an association with increased AQP3 expression and IL-33 concentration accompanied by decreased survival in patients with sepsis.

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Demystifying the Role of Neuroinflammatory Mediators as Biomarkers for Diagnosis, Prognosis, and Treatment of Alzheimer’s Disease: A Review

Doke,

Lamkhade,

Vinchurkar

et al. 2024

ACS Pharmacol. Transl. Sci.

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Neuroinflammatory mediators play a pivotal role in the pathogenesis of Alzheimer's Disease (AD), influencing its onset, progression, and severity. The precise mechanisms behind AD are still not fully understood, leading current treatments to focus mainly on managing symptoms rather than preventing or curing the condition. The amyloid and tau hypotheses are the most widely accepted explanations for AD pathology; however, they do not completely account for the neuronal degeneration observed in AD. Growing evidence underscores the crucial role of neuroinflammation in the pathology of AD. The neuroinflammatory hypothesis presents a promising new approach to understanding the mechanisms driving AD. This review examines the importance of neuroinflammatory biomarkers in the diagnosis, prognosis, and treatment of AD. It delves into the mechanisms underlying neuroinflammation in AD, highlighting the involvement of various mediators such as cytokines, chemokines, and ROS. Additionally, this review discusses the potential of neuroinflammatory biomarkers as diagnostic tools, prognostic indicators, and therapeutic targets for AD management. By understanding the intricate interplay between neuroinflammation and AD pathology, this review aims to help in the development of efficient diagnostic and treatment plans to fight this debilitating neurological condition. Furthermore, it elaborates recent advancements in neuroimaging techniques and biofluid analysis for the identification and monitoring of neuroinflammatory biomarkers in AD patients.

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Research progress on the activation mechanism of NLRP3 inflammasome in septic cardiomyopathy

Cited by 3 publications

References 93 publications

Oxidative Stress in Sepsis: A Focus on Cardiac Pathology

Oxidative Stress in Sepsis: A Focus on Cardiac Pathology

The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion

Demystifying the Role of Neuroinflammatory Mediators as Biomarkers for Diagnosis, Prognosis, and Treatment of Alzheimer’s Disease: A Review

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