Research Progress on the Antidepressant Effects of Baicalin and Its Aglycone Baicalein: A Systematic Review of the Biological Mechanisms

Wang, Chen; Gao, Ming-Qi

doi:10.1007/s11064-023-04026-3

Cited by 5 publications

(5 citation statements)

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“…Derived from Scutellariabaicalensis Georgi, baicalein, also called 5,6,7-trihydroxyflavone [124]. Its anti-angiogenesis activity is attributed to the VEGF suppression and FGFR-2, and the downregulation of corresponding factors such as FGF2, VEGF, MMP1, TEK, and ANGPT1 [47].…”

Section: Chemical Componentsmentioning

confidence: 99%

Flavonoids with Anti-Angiogenesis Function in Cancer

Wei,

Zhang

2024

Molecules

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The formation of new blood vessels, known as angiogenesis, significantly impacts the development of multiple types of cancer. Consequently, researchers have focused on targeting this process to prevent and treat numerous disorders. However, most existing anti-angiogenic treatments rely on synthetic compounds and humanized monoclonal antibodies, often expensive or toxic, restricting patient access to these therapies. Hence, the pursuit of discovering new, affordable, less toxic, and efficient anti-angiogenic compounds is imperative. Numerous studies propose that natural plant-derived products exhibit these sought-after characteristics. The objective of this review is to delve into the anti-angiogenic properties exhibited by naturally derived flavonoids from plants, along with their underlying molecular mechanisms of action. Additionally, we summarize the structure, classification, and the relationship between flavonoids with their signaling pathways in plants as anti-angiogenic agents, including main HIF-1α/VEGF/VEGFR2/PI3K/AKT, Wnt/β-catenin, JNK1/STAT3, and MAPK/AP-1 pathways. Nonetheless, further research and innovative approaches are required to enhance their bioavailability for clinical application.

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Section: Chemical Componentsmentioning

confidence: 99%

Flavonoids with Anti-Angiogenesis Function in Cancer

Wei,

Zhang

2024

Molecules

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“…These flavonoids are found in the root of the traditional Chinese medicine, Scutellaria baicalensis Georgi, one of the components of Xiao-chai-hu-tang (XCHT) that has been widely used clinically in depressive disorders in China [12]. In addition, XCHT has been shown to significantly ameliorate depressive-like behavior in a rat model by improving the serotoninergic function and neurotrophic factors in the hippocampus [12,13]. In Thailand, baicalin and baicalein can be found in Oroxylum indicum (L.) Kurz, a plant belonging to the family Bignoniaceae.…”

Section: Introductionmentioning

confidence: 99%

“…Interestingly, the higher expression of serine/threonine-protein kinase 1 (SGK-1), another protein regulated by glucocorticoid (GC) activities, can weaken neuroplasticity in related brain regions [9]. Baicalin (baicalein-7-O-glucuronide) and its aglycone, baicalein (5,6,7-trihydroxyflavone), present the highest biological activities compared with other compounds, especially in the treatment of neurodegenerative diseases, such as depression or cognitive impairment (Figure 1) [10][11][12]. Various studies have suggested that baicalin ameliorates the depression-like behaviors in animal models with multiple mechanisms of action such as regulating the HPA axis, promoting neurogenesis, improving mitochondrial dysfunction, and suppressing neuronal inflammation and oxidative stress, as well as attenuating neuronal apoptosis [12].…”

Section: Introductionmentioning

confidence: 99%

“…Baicalin (baicalein-7-O-glucuronide) and its aglycone, baicalein (5,6,7-trihydroxyflavone), present the highest biological activities compared with other compounds, especially in the treatment of neurodegenerative diseases, such as depression or cognitive impairment (Figure 1) [10][11][12]. Various studies have suggested that baicalin ameliorates the depression-like behaviors in animal models with multiple mechanisms of action such as regulating the HPA axis, promoting neurogenesis, improving mitochondrial dysfunction, and suppressing neuronal inflammation and oxidative stress, as well as attenuating neuronal apoptosis [12]. These flavonoids are found in the root of the traditional Chinese medicine, Scutellaria baicalensis Georgi, one of the components of Xiao-chai-hu-tang (XCHT) that has been widely used clinically in depressive disorders in China [12].…”

Section: Introductionmentioning

confidence: 99%

“…Various studies have suggested that baicalin ameliorates the depression-like behaviors in animal models with multiple mechanisms of action such as regulating the HPA axis, promoting neurogenesis, improving mitochondrial dysfunction, and suppressing neuronal inflammation and oxidative stress, as well as attenuating neuronal apoptosis [12]. These flavonoids are found in the root of the traditional Chinese medicine, Scutellaria baicalensis Georgi, one of the components of Xiao-chai-hu-tang (XCHT) that has been widely used clinically in depressive disorders in China [12]. In addition, XCHT has been shown to significantly ameliorate depressive-like behavior in a rat model by improving the serotoninergic function and neurotrophic factors in the hippocampus [12,13].…”

Section: Introductionmentioning

confidence: 99%

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Antidepressant-like Effect of Oroxylum indicum Seed Extract in Mice Model of Unpredictable Chronic Mild Stress

Chalermwongkul,

Khamphukdee,

Maneenet

et al. 2023

Nutrients

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Major depressive disorder (MDD) is one life-threatening disorder that is prevalent worldwide. The evident etiology of this disease is still poorly understood. Currently, herbal medicine is gaining more interest as an alternative antidepressant. Oroxylum indicum, which is used in traditional medicine and contains a potential antidepressive compound, baicalein, could have an antidepressive property. An in vitro monoamine oxidase-A (MAO-A) inhibitory assay was used to preliminarily screening for the antidepressant effect of O. indicum seed (OIS) extract. Mice were subjected to unpredictable chronic mild stress (UCMS) for 6 weeks, and the daily administration of OIS extract started from week 4. The mechanisms involved in the antidepressive activity were investigated. The OIS extract significantly alleviated anhedonia and despair behaviors in the UCMS-induced mouse model via two possible pathways: (i) it normalized the HPA axis function via the restoration of negative feedback (decreased FKBP5 and increased GR expressions) and the reduction in the glucocorticoid-related negative gene (SGK-1), and (ii) it improved neurogenesis via the escalation of BDNF and CREB expressions in the hippocampus and the frontal cortex. In addition, an HPLC analysis of the OIS extract showed the presence of baicalin, baicalein, and chrysin as major constituents. All of the results obtained from this study emphasize the potential of OIS extract containing baicalin and baicalein as an effective and novel alternative treatment for MDD.

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