Research progress on the circRNA‑mediated regulation of tumor angiogenesis through ceRNA mechanisms (Review)

Meng, Dandan; Jia, Ruixue; Yuan, Shenfang; Wei, Mengjuan; Bao, Xingxun; Zhu, Chengfeng; Wang, Wantao; Li, Zongxin

doi:10.3892/or.2022.8449

Cited by 8 publications

(3 citation statements)

References 90 publications

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“…The growth and metastasis of cancer cells rely on tumor angiogenesis, a process facilitated by the collective action of cancer cells, stromal cells, and their secretions. Given that VEGF is pivotal in promoting cancer cell growth through angiogenesis, circRNAs exert influence by directly or indirectly modulating VEGF expression levels 95 , 96 . Gong et al discovered that circBFAR promotes ki-67, MMP2, and VEGFA protein expression by binding to miR-31-5p, facilitating the generation of new blood vessels in LSCC 97 .…”

Section: Functional Roles and Mechanisms Of Circrna In Hnsccmentioning

confidence: 99%

Exploring the evolving roles and clinical significance of circRNAs in head and neck squamous cell carcinoma

Lei,

Guo,

Hao

et al. 2024

J. Cancer

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Section: Functional Roles and Mechanisms Of Circrna In Hnsccmentioning

confidence: 99%

Exploring the evolving roles and clinical significance of circRNAs in head and neck squamous cell carcinoma

Lei,

Guo,

Hao

et al. 2024

J. Cancer

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“…Growth factors are another subtype of transmitters in the crosstalk between tumor cells and TME. Tumor cells maintain their growth by absorbing the essential nutrition from the surrounding blood vessels; thus, angiogenesis is necessary for the initiation and progression of different tumors [ 212 ]. Angiogenic growth factors, such as VEGF, PDGF and fibroblast growth factor 2 (FGF2), interact with their receptors to activate the downstream signaling pathways to regulate angiogenesis [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

A review on the role of long non-coding RNA and microRNA network in clear cell renal cell carcinoma and its tumor microenvironment

Zhang

Ren

et al. 2023

Cancer Cell Int

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Renal cell carcinoma (RCC) is the second lethal urogenital malignancy with the increasing incidence and mortality in the world. Clear cell renal cell carcinoma (ccRCC) is one major subtype of RCC, which accounts for about 70 to 80% of all RCC cases. Although many innovative therapeutic options have emerged during the last few decades, the efficacy of these treatments for ccRCC patients is very limited. To date, the prognosis of patients with advanced or metastatic ccRCC is still poor. The 5-year survival rate of these patients remains less than 10%, which mainly attributes to the complexity and heterogeneity of the tumor microenvironment (TME). It has been demonstrated that long non-coding RNAs (lncRNAs) perform an indispensable role in the initiation and progression of various tumors. They mostly function as sponges for microRNAs (miRNAs) to regulate the expression of target genes, finally influence the growth, metastasis, apoptosis, drug resistance and TME of tumor cells. However, the role of lncRNA/miRNA/mRNA axis in the TME of ccRCC remains poorly understood. In this review, we summarized the biological function of lncRNA/miRNA/mRNA axis in the pathogenesis of ccRCC, then discussed how lncRNA/miRNA/mRNA axis regulate the TME, finally highlighted their potential application as novel biomarkers and therapeutic targets for ccRCC.

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“…CircRNA is widely involved in the regulation of sarcomeres, cell proliferation, differentiation, and apoptosis as a competitive endogenous RNA (ceRNA) (Meng et al, 2023). Hsa_circ_001783 promotes the progression of breast cancer cells by sponging miR-200c-3p (Z. .…”

Section: Introductionmentioning

confidence: 99%

CircGUCY2C regulates cofilin 1 by sponging miR-425-3p to promote the proliferation of porcine skeletal muscle satellite cells

Qi,

Dou,

et al. 2023

Arch. Anim. Breed.

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Abstract. Circular ribonucleic acids (or circRNAs) are an emerging class of endogenous noncoding RNAs that are involved in physiological and pathological processes. Increasing evidence suggests that circRNAs play an important regulatory role in skeletal muscle development and meat quality regulation. In this study, it was found that circGUCY2C exhibits a high expression level in the longissimus dorsi muscle. It shows resistance to RNase R and additionally promotes the mRNA expression of cyclin-dependent kinase 2 (CDK2) and proliferating cell nuclear antigen (PCNA). Specifically, it was observed that the overexpression of circGUCY2C could promote the transition of porcine skeletal muscle satellite cells into the S and G2 phases of the cell cycle and that it regulates the proliferation of porcine skeletal muscle satellite cells. In contrast, miR-425-3p plays the opposite role and has an inhibitory effect on the proliferation of porcine skeletal muscle satellite cells. MiR-425-3p has been described as a target of circGUCY2C; consequently, the depletion of miR-425-3p promoted the proliferation of porcine skeletal muscle satellite cells. CFL1 (cofilin 1) is a target of miR-425-3p, and circGUCY2C upregulated CFL1 expression by inhibiting miR-425-3p. Collectively, our research outcomes demonstrate that circGUCY2C significantly influences the proliferation of porcine skeletal muscle satellite cells by selectively targeting the miR-425-3p–CFL1 axis, and our work partially clarified the role of circGUCY2C in porcine skeletal muscle satellite cells. Thus, the study provides new insight into the function of circGUCY2C and adds to the knowledge of the post-transcriptional regulation of pork quality.

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Research progress on the circRNA‑mediated regulation of tumor angiogenesis through ceRNA mechanisms (Review)

Cited by 8 publications

References 90 publications

Exploring the evolving roles and clinical significance of circRNAs in head and neck squamous cell carcinoma

Exploring the evolving roles and clinical significance of circRNAs in head and neck squamous cell carcinoma

A review on the role of long non-coding RNA and microRNA network in clear cell renal cell carcinoma and its tumor microenvironment

CircGUCY2C regulates cofilin 1 by sponging miR-425-3p to promote the proliferation of porcine skeletal muscle satellite cells

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