Research Progress on the Mechanism of Natural Product Ingredients in the Treatment of Uveitis

Abstract

As the spectrum of ophthalmic diseases keeps changing, uveitis has gradually become one of the major blinding eye diseases in the world. Although the efficacy and safety of adalimumab and other biological agents in the treatment of uveitis have been proved in clinical studies, no biological agents have been approved for the treatment of uveitis by Chinese National Medical Products Administration (NMPA). The quality of life and prognosis of uveitis patients are affected by the adverse reactions of currently available immunosuppressive drugs. In recent years, it has become a research hotspot to select effective components for uveitis treatment from natural drugs. Based on the classification of chemical structure, the therapeutic effect and mechanism of natural drug components on uveitis were discussed in detail, in order to provide reference for basic drug development and clinical research.

Potential therapeutic effects of green tea (Camellia sinensis) in eye diseases, a review

“…Anti-TNF agents and monoclonal antibodies, including Adalimumab, Infliximab, and Daclizumab, are often necessary for the treatment of chronic, non-infectious patients, especially in ones associated with systemic inflammatory diseases [ 95 ]. Herbal remedies may also be considered for treating uveitis [ 96 ].…”

A comprehensive review of Tripterygium wilfordii hook. f. in the treatment of rheumatic and autoimmune diseases: Bioactive compounds, mechanisms of action, and future directions

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