Research Progress on the Mechanism of Intestinal Barrier Damage and Drug Therapy in a High Altitude Environment

Abstract

The plateau is a typical extreme environment with low temperature, low oxygen and high ultraviolet rays. The integrity of the intestinal barrier is the basis for the functioning of the intestine, which plays an important role in absorbing nutrients, maintaining the balance of intestinal flora, and blocking the invasion of toxins. Currently, there is increasing evidence that high altitude environments can enhance intestinal permeability and disrupt intestinal barrier integrity. This article mainly focuses on the regulation of the expression of HIF and tight junction proteins in the high altitude environment, which promotes the release of pro-inflammatory factors, especially the imbalance of intestinal flora caused by the high altitude environment. The mechanism of intestinal barrier damage and the drugs to protect the intestinal barrier are reviewed. Studying the mechanism of intestinal barrier damage in high altitude environment is not only conducive to understanding the mechanism of high altitude environment affecting intestinal barrier function, but also provides a more scientific medicine treatment method for intestinal damage caused by the special high altitude environment.

The mechanism of Lycii Cortex intervention in essential hypertension was analyzed based on metabolomics and gut microbiota

“…Lachnoclostridium is a type of probiotics in the gut microorganisms. It has the effect of resisting pathogenic microorganisms, increasing the body's immune function and resisting the invasion of foreign bacteria [25][26][27] . In this experiment, it was found that the abundance of Lachnoclostridium increased compared to the model group in SHR after administration of the extract of Lycii Cortex.…”