Research Progress on the Mechanism of Gut Microbiota in Liver Diseases

Abstract

Gut microbiota (GM) dysbiosis can lead to the development of many diseases, and maintaining the stability of the gut microbiota is essential for the body to resist damage from the external environment. The liver is intrinsically linked to the gastrointestinal tract through the biliary tract, portal vein, and body circulation, and this intrinsic link is known as the "gut-liver axis". This "communication" between the intestine and the liver is the key to maintaining normal liver metabolism and intestinal homeostasis, and the two influence each other as cause and effect. The gut microbiota participates in a series of physiopathological reactions through the gut-liver axis, which ultimately affects the occurrence of liver diseases. In this paper, we will describe the relationship between gut microbiota and various liver diseases as well as the mechanism of gut microbiota in liver diseases, to provide theoretical reference for the prevention and treatment of liver diseases.