Research Progress on the Pathogenesis of Premature Ovarian Failure: A Review

Abstract

Premature ovarian failure (POF) causes tremendous physical and psychological health problems in women worldwide. Many important scientific studies have shown that the pathogenesis of POF may be related to reproductive endocrine hormone levels, granulosa cell apoptosis, mitochondrial dysfunction, immune function, related signalling pathways, genes, and enzyme deficiencies. The modern treatment for POF is hormone replacement therapy, but this method has limitations and cannot meet the needs of patients with POF. Therefore, this paper reviews the research on POF in recent years, and by summarizing its mechanism, we search for a multiway and multimans treatment for POF to explore the optimal treatment plan.