Research Progress on the Pharmacological Action of Schisantherin A

Abstract

Schisantherin A (Sch A) is a dibenzocyclooctadiene lignan monomer isolated from the fruit of Schisandra chinensis (Turcz.) Baill. (S. chinensis). At present, many studies have shown that Sch A has a wide range of pharmacological effects, including its anti-Parkinson and anti-inflammatory effects and ability to protect the liver, protect against ischemia-reperfusion (I/R) injury, suppress osteoclast formation, and improve learning and memory. Its mechanism may be related to the antioxidant, anti-inflammatory, and antiapoptotic properties of Sch A through the MAPK, NF-κB, AKT/GSK3β, and PI3K/AKT pathways. This is the first review of the recent studies on the pharmacological mechanism of Sch A.

Effects of plant natural products on metabolic-associated fatty liver disease and the underlying mechanisms: a narrative review with a focus on the modulation of the gut microbiota

“…Schisantherin A is an active substance isolated from the fruit of Schisandra chinensis (Turcz.) Baill., a perennial deciduous woody liana with antiparkinsonian, anti-inflammatory, hepatoprotective, ischemia–reperfusion injury prevention and osteoclast formation inhibition effects ( Xiao et al., 2022 ). The hepatoprotective effects of schisantherin A may be achieved by improving gut inflammation and modulating the gut microbiota ( Yu S. et al., 2022 ).…”

Evaluation of the Effect of Phyto-Adaptogens on the Performance Capability of Outbred Female Mice

“…Основной группой биологически активных веществ извлечений из плодов лимонника китайского (Schizandra chinensis) являются лигнаны (схизандрины), которые способствуют увеличению активности супероксиддисмутазы, обеспечивают шунтирование потока электронов в дыхательной цепи [9,10].…”

Cardioprotective Potential of Berries of Schisandra chinensis Turcz. (Baill.), Their Components and Food Products

“…Various in vitro and in vivo studies have found them to demonstrate various antioxidative, anti-inflammatory, anticancer, and antiviral properties, among others. For example, S. chinensis has an inhibitory effect on cytochrome P450, family 3, subfamily A (CYP3A), and P-glycoprotein (P-gp), which can mediate metabolism or efflux of substrates, and may interact with many drugs [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. In addition, Nasser et al [ 9 ] described various biological properties of schisandrin B.…”